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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ylr427w. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AIM46
  • mitochondrion
  • biological_process
  • molecular_function
  • ARE1
  • endoplasmic reticulum
  • sterol metabolic process
  • sterol O-acyltransferase activity
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • FET4
  • integral to plasma membrane
  • plasma membrane
  • low-affinity iron ion transport
  • intracellular copper ion transport
  • copper ion import
  • iron ion transmembrane transporter activity
  • copper ion transmembrane transporter activity
  • FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • GRS1
  • cytoplasm
  • mitochondrion
  • glycyl-tRNA aminoacylation
  • transcription termination
  • glycine-tRNA ligase activity
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • IMD2
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • IMD3
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • IMD4
  • cytoplasm
  • biological_process
  • IMP dehydrogenase activity
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • MAG2
  • cytoplasm
  • DNA dealkylation involved in DNA repair
  • molecular_function
  • MGM101
  • mitochondrial chromosome
  • mitochondrion
  • mitochondrial nucleoid
  • DNA repair
  • mitochondrial genome maintenance
  • DNA binding
  • MSC3
  • cellular_component
  • reciprocal meiotic recombination
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NPL3
  • nucleus
  • cytoplasm
  • mRNA export from nucleus
  • pseudohyphal growth
  • poly(A) RNA binding
  • mRNA binding
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • PDC6
  • cytoplasm
  • ethanol metabolic process
  • pyruvate decarboxylase activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RRP12
  • nucleus
  • ribosome
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TIF4632
  • eukaryotic translation initiation factor 4F complex
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    eukaryotic translation initiation factor 4F complex 2.4994E-7 26 4 3 6292
    nucleolus 1.3002E-6 26 211 8 6292
    non-membrane-bounded organelle 3.3085E-5 26 959 13 6292
    intracellular non-membrane-bounded organelle 3.3085E-5 26 959 13 6292
    nuclear lumen 3.3288E-4 26 453 8 6292
    organelle lumen 8.7806E-4 26 660 9 6292
    intracellular organelle lumen 8.7806E-4 26 660 9 6292
    membrane-enclosed lumen 1.3459E-3 26 700 9 6292
    mitochondrial chromosome 8.248E-3 26 2 1 6292
    cytoplasmic chromosome 8.248E-3 26 2 1 6292
    Noc2p-Noc3p complex 8.248E-3 26 2 1 6292
    Noc1p-Noc2p complex 8.248E-3 26 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 5.6257E-6 26 346 9 6292
    ribonucleoprotein complex biogenesis 1.0638E-5 26 374 9 6292
    GTP biosynthetic process 1.6421E-5 26 2 2 6292
    translational initiation 2.3056E-5 26 42 4 6292
    rRNA metabolic process 2.0703E-4 26 137 5 6292
    GTP metabolic process 3.4048E-4 26 7 2 6292
    ncRNA metabolic process 5.057E-4 26 257 6 6292
    cellular component biogenesis 1.2649E-3 26 694 9 6292
    rRNA processing 1.7264E-3 26 128 4 6292
    purine ribonucleoside triphosphate biosynthetic process 3.6053E-3 26 22 2 6292
    purine nucleoside triphosphate biosynthetic process 3.6053E-3 26 22 2 6292
    low-affinity iron ion transport 4.1322E-3 26 1 1 6292
    ribonucleoside triphosphate biosynthetic process 4.2858E-3 26 24 2 6292
    purine ribonucleoside triphosphate metabolic process 5.4091E-3 26 27 2 6292
    purine nucleoside triphosphate metabolic process 5.4091E-3 26 27 2 6292
    nucleoside triphosphate biosynthetic process 5.4091E-3 26 27 2 6292
    ribonucleoside triphosphate metabolic process 6.2251E-3 26 29 2 6292
    glycyl-tRNA aminoacylation 8.248E-3 26 2 1 6292
    nucleoside triphosphate metabolic process 8.4934E-3 26 34 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    IMP dehydrogenase activity 6.2656E-8 26 3 3 6292
    translation initiation factor activity 3.7704E-6 26 27 4 6292
    translation factor activity, nucleic acid binding 2.7807E-5 26 44 4 6292
    nucleic acid binding 2.9909E-5 26 666 11 6292
    RNA binding 3.2099E-3 26 367 6 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.2166E-3 26 73 3 6292
    7S RNA binding 4.1322E-3 26 1 1 6292
    oxidoreductase activity, acting on CH-OH group of donors 4.3171E-3 26 81 3 6292
    glycine-tRNA ligase activity 8.248E-3 26 2 1 6292
    5S rRNA binding 8.248E-3 26 2 1 6292
    sterol O-acyltransferase activity 8.248E-3 26 2 1 6292
    NADPH dehydrogenase activity 8.248E-3 26 2 1 6292
    binding 9.6624E-3 26 1294 11 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle