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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ydr365c. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • CKA1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKA2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKB1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • ESF1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • ESF2
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • transcription regulator activity
  • HTB1
  • nuclear nucleosome
  • chromatin assembly or disassembly
  • postreplication repair
  • DNA binding
  • IMD3
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • LAA1
  • AP-1 adaptor complex
  • ribosome
  • clathrin-coated vesicle
  • protein localization
  • retrograde transport, endosome to Golgi
  • molecular_function
  • LHP1
  • nucleus
  • nucleolus
  • nucleoplasm
  • tRNA processing
  • RNA binding
  • MSS116
  • mitochondrial matrix
  • mitochondrion
  • RNA splicing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • PMA1
  • mitochondrion
  • membrane raft
  • plasma membrane
  • proton transport
  • regulation of pH
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • YCR087W
    YDR102C
    YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase CK2 complex 6.5439E-8 17 4 3 6292
    nucleolus 1.7999E-4 17 211 5 6292
    non-membrane-bounded organelle 1.902E-3 17 959 8 6292
    intracellular non-membrane-bounded organelle 1.902E-3 17 959 8 6292
    nuclear lumen 5.6662E-3 17 453 5 6292
    organelle lumen 5.8444E-3 17 660 6 6292
    intracellular organelle lumen 5.8444E-3 17 660 6 6292
    membrane-enclosed lumen 7.8098E-3 17 700 6 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    regulation of transcription from RNA polymerase I promoter 6.5439E-8 17 4 3 6292
    regulation of transcription from RNA polymerase III promoter 5.6973E-7 17 7 3 6292
    flocculation via cell wall protein-carbohydrate interaction 1.9436E-6 17 10 3 6292
    flocculation 2.668E-6 17 11 3 6292
    G2/M transition of mitotic cell cycle 5.7332E-5 17 29 3 6292
    transcription from RNA polymerase I promoter 6.3596E-5 17 30 3 6292
    transcription from RNA polymerase III promoter 1.3039E-4 17 38 3 6292
    chemical homeostasis 2.7177E-4 17 123 4 6292
    ion homeostasis 2.7177E-4 17 123 4 6292
    G1/S transition of mitotic cell cycle 2.9692E-4 17 50 3 6292
    RNA metabolic process 1.837E-3 17 954 8 6292
    interphase of mitotic cell cycle 2.0647E-3 17 97 3 6292
    interphase 2.0647E-3 17 97 3 6292
    protein amino acid phosphorylation 2.4518E-3 17 103 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.954E-3 17 1566 10 6292
    response to DNA damage stimulus 3.122E-3 17 236 4 6292
    cellular chemical homeostasis 3.6959E-3 17 119 3 6292
    cellular ion homeostasis 3.6959E-3 17 119 3 6292
    cellular homeostasis 3.7844E-3 17 120 3 6292
    GTP biosynthetic process 5.3968E-3 17 2 1 6292
    nucleic acid metabolic process 5.909E-3 17 1415 9 6292
    multi-organism process 6.1874E-3 17 143 3 6292
    cellular response to stress 6.5321E-3 17 290 4 6292
    cellular nitrogen compound metabolic process 7.731E-3 17 1770 10 6292
    nitrogen compound metabolic process 8.4622E-3 17 1791 10 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase CK2 activity 6.8716E-6 17 2 2 6292
    nucleic acid binding 1.5379E-4 17 666 8 6292
    RNA binding 2.6984E-4 17 367 6 6292
    obsolete_molecular_function 7.6889E-4 17 69 3 6292
    7S RNA binding 2.7018E-3 17 1 1 6292
    hydrogen-exporting ATPase activity, phosphorylative mechanism 5.3968E-3 17 2 1 6292
    5S rRNA binding 5.3968E-3 17 2 1 6292
    protein kinase CK2 regulator activity 5.3968E-3 17 2 1 6292
    IMP dehydrogenase activity 8.0849E-3 17 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle