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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Cka1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 33 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • CKA1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKA2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • CKB1
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • CKB2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 regulator activity
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ENP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • GDE1
  • cytoplasm
  • ribosome
  • glycerophospholipid catabolic process
  • glycerophosphocholine phosphodiesterase activity
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • HOT1
  • nuclear chromosome
  • hyperosmotic response
  • regulation of transcription from RNA polymerase II promoter
  • specific RNA polymerase II transcription factor activity
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • MRPL1
  • mitochondrion
  • mitochondrial large ribosomal subunit
  • aerobic respiration
  • translation
  • structural constituent of ribosome
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • PDI1
  • endoplasmic reticulum lumen
  • protein folding
  • protein disulfide isomerase activity
  • protein disulfide oxidoreductase activity
  • POB3
  • nucleus
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • chromatin remodeling
  • DNA-dependent DNA replication
  • chromatin assembly or disassembly
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • chromatin binding
  • POL2
  • replication fork
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA synthesis involved in DNA repair
  • chromatin silencing at telomere
  • nucleotide binding
  • nucleic acid binding
  • DNA binding
  • zinc ion binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • metal ion binding
  • double-stranded DNA binding
  • transferase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • RRP14
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosomal small subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • RRP5
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • snoRNA binding
  • rRNA primary transcript binding
  • SFP1
  • nucleus
  • cytoplasm
  • transcription from RNA polymerase III promoter
  • regulation of cell size
  • ribosome biogenesis
  • transcription factor activity
  • SPT16
  • FACT complex
  • nuclear chromatin
  • alpha DNA polymerase:primase complex
  • transcription elongation factor complex
  • transcription initiation from RNA polymerase II promoter
  • RNA elongation from RNA polymerase II promoter
  • transcription elongation regulator activity
  • RNA polymerase II transcription elongation factor activity
  • SSF1
  • nucleolus
  • conjugation with cellular fusion
  • regulation of cell size
  • ribosomal large subunit assembly
  • rRNA binding
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TRL1
  • nuclear inner membrane
  • nucleoplasm
  • UFP-specific transcription factor mRNA processing during unfolded protein response
  • tRNA splicing, via endonucleolytic cleavage and ligation
  • GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity
  • 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
  • RNA ligase (ATP) activity
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • VMR1
  • mitochondrion
  • integral to membrane
  • ribosome
  • transport
  • ATPase activity, coupled to transmembrane movement of substances
  • VPS73
  • mitochondrion
  • protein targeting to vacuole
  • molecular_function
  • WTM2
  • nucleus
  • regulation of meiosis
  • transcription corepressor activity
  • YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 6.9127E-13 33 211 14 6292
    nuclear lumen 7.3611E-13 33 453 18 6292
    non-membrane-bounded organelle 2.5585E-12 33 959 23 6292
    intracellular non-membrane-bounded organelle 2.5585E-12 33 959 23 6292
    organelle lumen 3.0438E-12 33 660 20 6292
    intracellular organelle lumen 3.0438E-12 33 660 20 6292
    membrane-enclosed lumen 9.1996E-12 33 700 20 6292
    protein kinase CK2 complex 6.272E-10 33 4 4 6292
    nuclear part 4.619E-9 33 1103 21 6292
    nuclear replication fork 2.8643E-6 33 20 4 6292
    nucleus 1.2252E-5 33 2041 23 6292
    FACT complex 2.6678E-5 33 2 2 6292
    replication fork 6.1007E-5 33 42 4 6292
    intracellular organelle part 9.4172E-5 33 2282 23 6292
    organelle part 9.4172E-5 33 2282 23 6292
    replisome 1.0168E-4 33 18 3 6292
    nuclear replisome 1.0168E-4 33 18 3 6292
    protein-DNA complex 2.037E-4 33 57 4 6292
    intracellular part 3.2895E-4 33 4938 33 6292
    intracellular 4.2117E-4 33 4975 33 6292
    alpha DNA polymerase:primase complex 5.511E-4 33 7 2 6292
    macromolecular complex 1.473E-3 33 1635 17 6292
    nuclear membrane 1.5417E-3 33 97 4 6292
    membrane-bounded organelle 1.8798E-3 33 3771 28 6292
    intracellular membrane-bounded organelle 1.8798E-3 33 3771 28 6292
    intracellular organelle 2.6294E-3 33 4070 29 6292
    organelle 2.644E-3 33 4071 29 6292
    nuclear chromosome 6.19E-3 33 228 5 6292
    cell part 6.2364E-3 33 5397 33 6292
    transcription elongation factor complex 6.3001E-3 33 23 2 6292
    cell 6.3134E-3 33 5399 33 6292
    nuclear chromatin 6.3697E-3 33 73 3 6292
    chromatin 7.3859E-3 33 77 3 6292
    protein complex 9.702E-3 33 1137 12 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 3.9592E-11 33 346 15 6292
    ribonucleoprotein complex biogenesis 1.2031E-10 33 374 15 6292
    regulation of transcription from RNA polymerase I promoter 6.272E-10 33 4 4 6292
    cellular component biogenesis 9.9007E-10 33 694 18 6292
    regulation of transcription from RNA polymerase III promoter 2.171E-8 33 7 4 6292
    RNA metabolic process 2.2627E-8 33 954 19 6292
    gene expression 7.6229E-8 33 1283 21 6292
    flocculation via cell wall protein-carbohydrate interaction 1.2882E-7 33 10 4 6292
    flocculation 2.0169E-7 33 11 4 6292
    rRNA metabolic process 3.6121E-7 33 137 8 6292
    transcription from RNA polymerase III promoter 1.2842E-6 33 38 5 6292
    nucleic acid metabolic process 2.588E-6 33 1415 20 6292
    rRNA processing 3.3655E-6 33 128 7 6292
    ncRNA metabolic process 4.4829E-6 33 257 9 6292
    ncRNA processing 1.0833E-5 33 215 8 6292
    G2/M transition of mitotic cell cycle 1.3582E-5 33 29 4 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3627E-5 33 1566 20 6292
    transcription from RNA polymerase I promoter 1.5614E-5 33 30 4 6292
    ribosomal large subunit biogenesis 1.9112E-5 33 65 5 6292
    macromolecule metabolic process 3.7228E-5 33 2349 24 6292
    transcription 6.9212E-5 33 552 11 6292
    cellular nitrogen compound metabolic process 9.4168E-5 33 1770 20 6292
    cellular macromolecule metabolic process 9.6407E-5 33 2285 23 6292
    nitrogen compound metabolic process 1.129E-4 33 1791 20 6292
    G1/S transition of mitotic cell cycle 1.2187E-4 33 50 4 6292
    cellular process 1.3165E-4 33 4426 32 6292
    transcription, DNA-dependent 1.6731E-4 33 503 10 6292
    RNA biosynthetic process 1.8164E-4 33 508 10 6292
    primary metabolic process 4.8623E-4 33 2896 25 6292
    RNA processing 5.9935E-4 33 380 8 6292
    cellular response to stress 6.237E-4 33 290 7 6292
    regulation of transcription 6.4273E-4 33 384 8 6292
    multi-organism process 8.0331E-4 33 143 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0733E-3 33 415 8 6292
    regulation of nitrogen compound metabolic process 1.0903E-3 33 416 8 6292
    response to DNA damage stimulus 1.2346E-3 33 236 6 6292
    cellular macromolecule biosynthetic process 1.5093E-3 33 1187 14 6292
    macromolecule biosynthetic process 1.5352E-3 33 1189 14 6292
    interphase of mitotic cell cycle 1.5417E-3 33 97 4 6292
    interphase 1.5417E-3 33 97 4 6292
    regulation of gene expression 1.6875E-3 33 445 8 6292
    protein amino acid phosphorylation 1.9242E-3 33 103 4 6292
    regulation of macromolecule biosynthetic process 1.973E-3 33 456 8 6292
    regulation of transcription, DNA-dependent 2.1467E-3 33 358 7 6292
    regulation of RNA metabolic process 2.3238E-3 33 363 7 6292
    metabolic process 2.3674E-3 33 3157 25 6292
    regulation of cellular biosynthetic process 2.4559E-3 33 472 8 6292
    regulation of biosynthetic process 2.489E-3 33 473 8 6292
    cellular response to stimulus 2.9684E-3 33 379 7 6292
    regulation of macromolecule metabolic process 3.0284E-3 33 488 8 6292
    cellular ion homeostasis 3.2581E-3 33 119 4 6292
    cellular chemical homeostasis 3.2581E-3 33 119 4 6292
    cellular homeostasis 3.3581E-3 33 120 4 6292
    response to stress 3.3939E-3 33 497 8 6292
    maturation of SSU-rRNA 3.4993E-3 33 59 3 6292
    cellular metabolic process 3.6657E-3 33 3033 24 6292
    chemical homeostasis 3.6705E-3 33 123 4 6292
    ion homeostasis 3.6705E-3 33 123 4 6292
    regulation of primary metabolic process 4.1786E-3 33 514 8 6292
    histone H3-K79 methylation 5.2448E-3 33 1 1 6292
    regulation of cellular metabolic process 5.3974E-3 33 536 8 6292
    regulation of metabolic process 6.1021E-3 33 547 8 6292
    DNA-dependent DNA replication 8.7845E-3 33 82 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    protein kinase CK2 activity 2.6678E-5 33 2 2 6292
    protein kinase CK2 regulator activity 2.6678E-5 33 2 2 6292
    obsolete_molecular_function 4.2649E-4 33 69 4 6292
    nucleic acid binding 1.5854E-3 33 666 10 6292
    phosphoric diester hydrolase activity 2.6841E-3 33 15 2 6292
    rRNA binding 3.0575E-3 33 16 2 6292
    binding 3.5472E-3 33 1294 14 6292
    RNA ligase (ATP) activity 5.2448E-3 33 1 1 6292
    GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity 5.2448E-3 33 1 1 6292
    polynucleotide kinase activity 5.2448E-3 33 1 1 6292
    GTP-dependent polynucleotide kinase activity 5.2448E-3 33 1 1 6292
    polyribonucleotide kinase activity 5.2448E-3 33 1 1 6292
    RNA ligase activity 5.2448E-3 33 1 1 6292
    glycerophosphocholine phosphodiesterase activity 5.2448E-3 33 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle