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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Swd3. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
HPR1
  • Cdc73/Paf1 complex
  • THO complex
  • mRNA export from nucleus
  • DNA recombination
  • telomere maintenance
  • response to DNA damage stimulus
  • RNA elongation from RNA polymerase II promoter
  • nucleic acid binding
  • PSK2
  • cytoplasm
  • mitochondrion
  • hexose metabolic process
  • protein amino acid phosphorylation
  • protein serine/threonine kinase activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • SET1
  • Set1C/COMPASS complex
  • ascospore formation
  • chromatin silencing at rDNA
  • histone methylation
  • telomere maintenance
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • peptidyl-lysine dimethylation
  • histone methyltransferase activity (H3-K4 specific)
  • histone methyltransferase activity
  • protein-lysine N-methyltransferase activity
  • SFP1
  • nucleus
  • cytoplasm
  • transcription from RNA polymerase III promoter
  • regulation of cell size
  • ribosome biogenesis
  • transcription factor activity
  • SGS1
  • nucleolus
  • RecQ helicase-Topo III complex
  • meiotic chromosome segregation
  • mitotic sister chromatid segregation
  • telomere maintenance via recombination
  • response to DNA damage stimulus
  • replicative cell aging
  • DNA unwinding involved in replication
  • ATP-dependent DNA helicase activity
  • SUV3
  • mitochondrial matrix
  • mitochondrion
  • RNA catabolic process
  • ATP-dependent RNA helicase activity
  • SWD3
  • Set1C/COMPASS complex
  • histone methylation
  • telomere maintenance
  • chromatin silencing at telomere
  • histone methyltransferase activity (H3-K4 specific)
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Set1C/COMPASS complex 3.9462E-5 8 8 2 6292
    methyltransferase complex 3.9462E-5 8 8 2 6292
    histone methyltransferase complex 3.9462E-5 8 8 2 6292
    organelle lumen 5.3463E-4 8 660 5 6292
    intracellular organelle lumen 5.3463E-4 8 660 5 6292
    membrane-enclosed lumen 7.0576E-4 8 700 5 6292
    nuclear lumen 1.4695E-3 8 453 4 6292
    nucleoplasm part 2.8239E-3 8 245 3 6292
    nucleoplasm 3.4955E-3 8 264 3 6292
    RecQ helicase-Topo III complex 3.8101E-3 8 3 1 6292
    THO complex 5.0773E-3 8 4 1 6292
    chromatin remodeling complex 6.4515E-3 8 99 2 6292
    protein complex 6.5954E-3 8 1137 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    regulation of biological quality 2.2653E-4 8 551 5 6292
    anatomical structure homeostasis 2.5313E-4 8 286 4 6292
    telomere organization 2.5313E-4 8 286 4 6292
    telomere maintenance 2.5313E-4 8 286 4 6292
    histone methylation 2.6574E-4 8 20 2 6292
    cellular macromolecule metabolic process 3.0018E-4 8 2285 8 6292
    macromolecule metabolic process 3.7455E-4 8 2349 8 6292
    protein amino acid alkylation 3.8504E-4 8 24 2 6292
    protein amino acid methylation 3.8504E-4 8 24 2 6292
    homeostatic process 9.8908E-4 8 408 4 6292
    macromolecule methylation 1.2446E-3 8 43 2 6292
    methylation 1.2446E-3 8 43 2 6292
    peptidyl-lysine dimethylation 1.2715E-3 8 1 1 6292
    primary metabolic process 2.0036E-3 8 2896 8 6292
    one-carbon metabolic process 2.0312E-3 8 55 2 6292
    chromatin silencing at telomere 2.0312E-3 8 55 2 6292
    transcription, DNA-dependent 2.1776E-3 8 503 4 6292
    RNA biosynthetic process 2.2596E-3 8 508 4 6292
    nucleic acid metabolic process 2.3473E-3 8 1415 6 6292
    peptidyl-lysine methylation 2.5415E-3 8 2 1 6292
    cellular metabolic process 2.9013E-3 8 3033 8 6292
    RNA metabolic process 2.9766E-3 8 954 5 6292
    transcription 3.0791E-3 8 552 4 6292
    chromosome organization 3.1417E-3 8 555 4 6292
    peptidyl-lysine modification 3.8101E-3 8 3 1 6292
    DNA metabolic process 3.8176E-3 8 585 4 6292
    metabolic process 3.9991E-3 8 3157 8 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.1016E-3 8 1566 6 6292
    covalent chromatin modification 5.1269E-3 8 88 2 6292
    histone modification 5.1269E-3 8 88 2 6292
    negative regulation of gene expression, epigenetic 6.579E-3 8 100 2 6292
    gene silencing 6.579E-3 8 100 2 6292
    regulation of gene expression, epigenetic 6.579E-3 8 100 2 6292
    chromatin silencing 6.579E-3 8 100 2 6292
    cellular nitrogen compound metabolic process 7.9712E-3 8 1770 6 6292
    cellular macromolecule biosynthetic process 7.9943E-3 8 1187 5 6292
    macromolecule biosynthetic process 8.0545E-3 8 1189 5 6292
    post-translational protein modification 8.1895E-3 8 357 3 6292
    DNA recombination 8.4845E-3 8 114 2 6292
    nitrogen compound metabolic process 8.4927E-3 8 1791 6 6292
    biological regulation 8.8033E-3 8 1213 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    histone methyltransferase activity (H3-K4 specific) 3.9462E-5 8 8 2 6292
    histone methyltransferase activity 5.0705E-5 8 9 2 6292
    histone-lysine N-methyltransferase activity 5.0705E-5 8 9 2 6292
    lysine N-methyltransferase activity 1.0958E-4 8 13 2 6292
    protein-lysine N-methyltransferase activity 1.0958E-4 8 13 2 6292
    protein methyltransferase activity 2.6574E-4 8 20 2 6292
    N-methyltransferase activity 4.1826E-4 8 25 2 6292
    ATP-dependent helicase activity 1.5498E-3 8 48 2 6292
    purine NTP-dependent helicase activity 1.5498E-3 8 48 2 6292
    S-adenosylmethionine-dependent methyltransferase activity 3.0012E-3 8 67 2 6292
    helicase activity 4.5722E-3 8 83 2 6292
    methyltransferase activity 6.0761E-3 8 96 2 6292
    transferase activity, transferring one-carbon groups 6.4515E-3 8 99 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle