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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Sap185. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARP4
  • nucleus
  • nuclear chromatin
  • NuA4 histone acetyltransferase complex
  • Swr1 complex
  • Ino80 complex
  • DNA repair
  • chromatin remodeling
  • regulation of transcription, DNA-dependent
  • histone acetylation
  • chromatin organization
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • ATP-dependent 5'-3' DNA helicase activity
  • chromatin binding
  • ATE1
  • cytoplasm
  • protein modification process
  • protein arginylation
  • arginyltransferase activity
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • CKA2
  • protein kinase CK2 complex
  • G2/M transition of mitotic cell cycle
  • G1/S transition of mitotic cell cycle
  • flocculation via cell wall protein-carbohydrate interaction
  • protein amino acid phosphorylation
  • response to DNA damage stimulus
  • regulation of transcription from RNA polymerase III promoter
  • regulation of transcription from RNA polymerase I promoter
  • cellular ion homeostasis
  • protein kinase CK2 activity
  • EAF1
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • chromatin modification
  • DNA repair
  • molecular_function
  • EPL1
  • NuA4 histone acetyltransferase complex
  • Piccolo NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • ESA1
  • NuA4 histone acetyltransferase complex
  • Piccolo NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
  • DNA repair
  • RNA elongation
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • HRR25
  • nucleus
  • plasma membrane
  • DNA repair
  • nuclear division
  • ribosomal small subunit biogenesis
  • chromosome segregation
  • mitosis
  • meiosis
  • casein kinase activity
  • POR1
  • integral to mitochondrial outer membrane
  • mitochondrion
  • mitochondrial outer membrane
  • ion transport
  • aerobic respiration
  • mitochondrion organization
  • voltage-gated anion channel activity
  • SAP185
  • cytoplasm
  • mitochondrion
  • G1/S transition of mitotic cell cycle
  • protein serine/threonine phosphatase activity
  • SIT4
  • nucleus
  • cytoplasm
  • DNA repair
  • G1/S transition of mitotic cell cycle
  • cellular cell wall organization
  • telomere maintenance
  • intracellular protein kinase cascade
  • protein amino acid phosphorylation
  • replicative cell aging
  • actin cytoskeleton organization
  • protein serine/threonine phosphatase activity
  • TAF14
  • SWI/SNF complex
  • transcription factor TFIID complex
  • Ino80 complex
  • transcription factor TFIIF complex
  • histone acetyltransferase complex
  • chromatin remodeling
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TAF4
  • transcription factor TFIID complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription factor activity
  • TIP41
  • nucleus
  • cytoplasm
  • signal transduction
  • molecular_function
  • TRA1
  • NuA4 histone acetyltransferase complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • histone acetyltransferase complex
  • DNA repair
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
  • histone acetyltransferase activity
  • TUF1
  • mitochondrial matrix
  • mitochondrion
  • translational elongation
  • translation elongation factor activity
  • GTPase activity
  • YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    H4/H2A histone acetyltransferase complex 1.4884E-10 17 14 5 6292
    NuA4 histone acetyltransferase complex 1.4884E-10 17 14 5 6292
    histone acetyltransferase complex 9.5971E-10 17 44 6 6292
    nucleoplasm part 1.7352E-6 17 245 7 6292
    nucleoplasm 2.8661E-6 17 264 7 6292
    Piccolo NuA4 histone acetyltransferase complex 2.0582E-5 17 3 2 6292
    nuclear lumen 9.8647E-5 17 453 7 6292
    organelle lumen 1.4419E-4 17 660 8 6292
    intracellular organelle lumen 1.4419E-4 17 660 8 6292
    protein complex 2.0229E-4 17 1137 10 6292
    membrane-enclosed lumen 2.1891E-4 17 700 8 6292
    DNA helicase complex 3.7257E-4 17 11 2 6292
    Ino80 complex 3.7257E-4 17 11 2 6292
    transcription factor TFIID complex 7.0676E-4 17 15 2 6292
    nucleus 1.4135E-3 17 2041 12 6292
    macromolecular complex 4.1648E-3 17 1635 10 6292
    nuclear part 4.7403E-3 17 1103 8 6292
    transcription factor TFIIF complex 8.0849E-3 17 3 1 6292
    DNA-directed RNA polymerase II, holoenzyme 9.7129E-3 17 56 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    response to DNA damage stimulus 6.3188E-8 17 236 8 6292
    cellular response to stress 3.1292E-7 17 290 8 6292
    DNA repair 3.3166E-7 17 192 7 6292
    histone acetylation 2.0379E-6 17 36 4 6292
    cellular response to stimulus 2.4211E-6 17 379 8 6292
    chromatin modification 3.2137E-6 17 168 6 6292
    protein amino acid acetylation 5.5526E-6 17 46 4 6292
    chromatin organization 9.6313E-6 17 203 6 6292
    protein amino acid acylation 1.5156E-5 17 59 4 6292
    response to stress 1.8384E-5 17 497 8 6292
    post-translational protein modification 2.116E-5 17 357 7 6292
    covalent chromatin modification 7.3997E-5 17 88 4 6292
    histone modification 7.3997E-5 17 88 4 6292
    interphase of mitotic cell cycle 1.0831E-4 17 97 4 6292
    interphase 1.0831E-4 17 97 4 6292
    transcription from RNA polymerase II promoter 1.6342E-4 17 335 6 6292
    protein modification process 1.8219E-4 17 499 7 6292
    transcription, DNA-dependent 1.9159E-4 17 503 7 6292
    RNA biosynthetic process 2.039E-4 17 508 7 6292
    nucleic acid metabolic process 2.2727E-4 17 1415 11 6292
    regulation of transcription, DNA-dependent 2.3553E-4 17 358 6 6292
    regulation of RNA metabolic process 2.5413E-4 17 363 6 6292
    regulation of transcription from RNA polymerase II promoter 2.5887E-4 17 228 5 6292
    G1/S transition of mitotic cell cycle 2.9692E-4 17 50 3 6292
    transcription 3.428E-4 17 552 7 6292
    regulation of transcription 3.4543E-4 17 384 6 6292
    chromosome organization 3.5455E-4 17 555 7 6292
    response to stimulus 4.1181E-4 17 766 8 6292
    macromolecule modification 4.1378E-4 17 569 7 6292
    mitotic cell cycle 4.3561E-4 17 255 5 6292
    DNA metabolic process 4.9107E-4 17 585 7 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.2585E-4 17 415 6 6292
    regulation of nitrogen compound metabolic process 5.3271E-4 17 416 6 6292
    regulation of cellular process 5.3754E-4 17 796 8 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.8919E-4 17 1566 11 6292
    regulation of biological process 6.8209E-4 17 824 8 6292
    regulation of gene expression 7.6444E-4 17 445 6 6292
    cellular protein metabolic process 7.8055E-4 17 1074 9 6292
    regulation of macromolecule biosynthetic process 8.7058E-4 17 456 6 6292
    cellular macromolecule metabolic process 8.7181E-4 17 2285 13 6292
    regulation of cellular biosynthetic process 1.0452E-3 17 472 6 6292
    regulation of biosynthetic process 1.057E-3 17 473 6 6292
    organelle organization 1.1236E-3 17 1127 9 6292
    macromolecule metabolic process 1.1807E-3 17 2349 13 6292
    protein metabolic process 1.1928E-3 17 1136 9 6292
    regulation of macromolecule metabolic process 1.2461E-3 17 488 6 6292
    regulation of primary metabolic process 1.6355E-3 17 514 6 6292
    cellular macromolecule biosynthetic process 1.6555E-3 17 1187 9 6292
    macromolecule biosynthetic process 1.6764E-3 17 1189 9 6292
    cellular nitrogen compound metabolic process 1.8041E-3 17 1770 11 6292
    RNA metabolic process 1.837E-3 17 954 8 6292
    nitrogen compound metabolic process 2.0053E-3 17 1791 11 6292
    regulation of cellular metabolic process 2.0334E-3 17 536 6 6292
    regulation of metabolic process 2.2585E-3 17 547 6 6292
    cellular process 2.5051E-3 17 4426 17 6292
    cell cycle phase 2.523E-3 17 376 5 6292
    protein arginylation 2.7018E-3 17 1 1 6292
    gene expression 2.9315E-3 17 1283 9 6292
    cellular metabolic process 4.1361E-3 17 3033 14 6292
    metabolic process 6.562E-3 17 3157 14 6292
    cell cycle process 7.9048E-3 17 490 5 6292
    biological regulation 8.6353E-3 17 1213 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    lysine N-acetyltransferase activity 8.4972E-8 17 17 4 6292
    histone acetyltransferase activity 8.4972E-8 17 17 4 6292
    N-acetyltransferase activity 1.4227E-6 17 33 4 6292
    N-acyltransferase activity 2.5452E-6 17 38 4 6292
    transferase activity, transferring acyl groups 6.811E-6 17 107 5 6292
    acetyltransferase activity 7.7844E-6 17 50 4 6292
    transferase activity, transferring acyl groups other than amino-acyl groups 8.8077E-5 17 92 4 6292
    acyltransferase activity 8.8077E-5 17 92 4 6292
    protein serine/threonine phosphatase activity 2.1497E-3 17 26 2 6292
    casein kinase activity 2.7018E-3 17 1 1 6292
    arginyltransferase activity 2.7018E-3 17 1 1 6292
    protein kinase CK2 activity 5.3968E-3 17 2 1 6292
    phosphoprotein phosphatase activity 5.8138E-3 17 43 2 6292
    translation factor activity, nucleic acid binding 6.081E-3 17 44 2 6292
    voltage-gated anion channel activity 8.0849E-3 17 3 1 6292
    anion channel activity 8.0849E-3 17 3 1 6292

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