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Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad59. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 23 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAC3
  • mitochondrion
  • mitochondrial inner membrane
  • anaerobic respiration
  • ATP:ADP antiporter activity
  • AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • ATP3
  • mitochondrial proton-transporting ATP synthase, central stalk
  • mitochondrion
  • ATP synthesis coupled proton transport
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
  • BEM2
  • mitochondrion
  • intracellular
  • small GTPase mediated signal transduction
  • cellular cell wall organization
  • microtubule cytoskeleton organization
  • budding cell bud growth
  • actin cytoskeleton organization
  • Rho GTPase activator activity
  • signal transducer activity
  • ECM10
  • mitochondrion
  • mitochondrial nucleoid
  • protein targeting to mitochondrion
  • protein refolding
  • molecular_function
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • HOM3
  • cytoplasm
  • response to drug
  • methionine metabolic process
  • threonine metabolic process
  • homoserine biosynthetic process
  • aspartate kinase activity
  • HOR2
  • nucleus
  • cytoplasm
  • carbohydrate metabolic process
  • response to osmotic stress
  • glycerol biosynthetic process
  • glycerol-1-phosphatase activity
  • ILV2
  • mitochondrion
  • acetolactate synthase complex
  • branched chain family amino acid biosynthetic process
  • acetolactate synthase activity
  • FAD binding
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • PIL1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • protein localization
  • endocytosis
  • protein kinase inhibitor activity
  • PRB1
  • fungal-type vacuole lumen
  • fungal-type vacuole
  • cellular response to starvation
  • sporulation resulting in formation of a cellular spore
  • vacuolar protein catabolic process
  • serine-type endopeptidase activity
  • PTC3
  • nucleus
  • cytoplasm
  • inactivation of MAPK activity involved in osmosensory signaling pathway
  • protein amino acid dephosphorylation
  • regulation of cyclin-dependent protein kinase activity
  • protein serine/threonine phosphatase activity
  • phosphoprotein phosphatase activity
  • metal ion binding
  • catalytic activity
  • hydrolase activity
  • RAD52
  • nucleus
  • nuclear chromosome
  • meiotic DNA recombinase assembly
  • double-strand break repair via break-induced replication
  • double-strand break repair via single-strand annealing
  • telomere maintenance via recombination
  • double-strand break repair via synthesis-dependent strand annealing
  • DNA recombinase assembly
  • postreplication repair
  • DNA strand annealing activity
  • recombinase activity
  • RAD59
  • nucleus
  • double-strand break repair via break-induced replication
  • double-strand break repair via single-strand annealing
  • telomere maintenance via recombination
  • protein binding
  • DNA strand annealing activity
  • RHR2
  • nucleus
  • cytoplasm
  • response to drug
  • response to osmotic stress
  • glycerol biosynthetic process
  • glycerol-1-phosphatase activity
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • SEC53
  • cytosol
  • protein targeting to ER
  • phosphomannomutase activity
  • TEF4
  • mitochondrion
  • ribosome
  • eukaryotic translation elongation factor 1 complex
  • translational elongation
  • translation elongation factor activity
  • UBA1
  • nucleus
  • cytoplasm
  • ubiquitin cycle
  • ubiquitin activating enzyme activity
  • VMA8
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • vacuolar acidification
  • proton-transporting ATPase activity, rotational mechanism
  • YER138C
  • retrotransposon nucleocapsid
  • transposition, RNA-mediated
  • DNA-directed DNA polymerase activity
  • RNA-directed DNA polymerase activity
  • RNA binding
  • protein binding
  • ribonuclease activity
  • peptidase activity
  • YPT31
  • endosome
  • Golgi apparatus
  • mitochondrial outer membrane
  • vesicle-mediated transport
  • exocytosis
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proton-transporting two-sector ATPase complex, catalytic domain 9.7297E-4 23 13 2 6292
    cytoplasm 1.8805E-3 23 3552 20 6292
    intracellular part 3.7561E-3 23 4938 23 6292
    intracellular 4.4613E-3 23 4975 23 6292
    proton-transporting two-sector ATPase complex 7.0682E-3 23 35 2 6292
    eisosome 7.2981E-3 23 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    polyol biosynthetic process 7.6359E-5 23 4 2 6292
    alditol biosynthetic process 7.6359E-5 23 4 2 6292
    glycerol biosynthetic process 7.6359E-5 23 4 2 6292
    response to stress 2.4224E-4 23 497 8 6292
    double-strand break repair via break-induced replication 4.5308E-4 23 9 2 6292
    double-strand break repair via single-strand annealing 4.5308E-4 23 9 2 6292
    glycerol metabolic process 5.6509E-4 23 10 2 6292
    alditol metabolic process 5.6509E-4 23 10 2 6292
    response to abiotic stimulus 7.6513E-4 23 117 4 6292
    response to stimulus 9.3562E-4 23 766 9 6292
    telomere maintenance via recombination 1.4869E-3 23 16 2 6292
    polyol metabolic process 1.8874E-3 23 18 2 6292
    fermentation 2.3335E-3 23 20 2 6292
    response to osmotic stress 2.6169E-3 23 77 3 6292
    double-strand break repair via homologous recombination 2.8244E-3 23 22 2 6292
    recombinational repair 3.9386E-3 23 26 2 6292
    small molecule biosynthetic process 4.5395E-3 23 310 5 6292
    generation of precursor metabolites and energy 4.9876E-3 23 195 4 6292
    mitotic recombination 6.3001E-3 23 33 2 6292
    non-recombinational repair 6.6791E-3 23 34 2 6292
    anaerobic respiration 7.2981E-3 23 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    glycerol-1-phosphatase activity 3.8264E-5 23 3 2 6292
    DNA strand annealing activity 7.6359E-5 23 4 2 6292
    single-stranded DNA binding 1.4869E-3 23 16 2 6292
    double-stranded DNA binding 3.0866E-3 23 23 2 6292
    phosphomannomutase activity 3.6554E-3 23 1 1 6292
    aspartate kinase activity 3.6554E-3 23 1 1 6292
    ubiquitin activating enzyme activity 3.6554E-3 23 1 1 6292
    phosphatase activity 3.7027E-3 23 87 3 6292
    phosphoric ester hydrolase activity 5.7876E-3 23 102 3 6292
    NADPH dehydrogenase activity 7.2981E-3 23 2 1 6292
    FAD binding 7.2981E-3 23 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle