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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Mus81. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADH2
  • cytoplasm
  • fermentation
  • ethanol metabolic process
  • NADH oxidation
  • alcohol dehydrogenase (NAD) activity
  • CDC16
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • CDC33
  • nucleus
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • translation initiation factor activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • FPR3
  • nucleolus
  • meiotic recombination checkpoint
  • peptidyl-prolyl cis-trans isomerase activity
  • HHF1, HHF2
  • nucleus
  • nucleoplasm part
  • nuclear nucleosome
  • chromosome
  • replication fork protection complex
  • chromatin remodeling complex
  • nucleosome
  • histone acetyltransferase complex
  • nucleoplasm
  • histone H3-K79 methylation
  • DNA repair
  • negative regulation of transcription
  • chromatin assembly or disassembly
  • positive regulation of transcription
  • nucleosome assembly
  • DNA binding
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRI1
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • LOC1
  • nucleus
  • intracellular mRNA localization
  • ribosomal large subunit biogenesis
  • mRNA binding
  • MES1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • methionyl-tRNA aminoacylation
  • methionine-tRNA ligase activity
  • MKT1
  • polysome
  • cytoplasm
  • interspecies interaction between organisms
  • positive regulation of translation
  • nuclease activity
  • MMS4
  • nucleus
  • Holliday junction resolvase complex
  • DNA repair
  • reciprocal meiotic recombination
  • DNA topological change
  • response to DNA damage stimulus
  • transcription coactivator activity
  • endonuclease activity
  • crossover junction endodeoxyribonuclease activity
  • MUS81
  • nucleus
  • Holliday junction resolvase complex
  • DNA repair
  • reciprocal meiotic recombination
  • DNA topological change
  • response to DNA damage stimulus
  • endonuclease activity
  • crossover junction endodeoxyribonuclease activity
  • NHP2
  • nuclear outer membrane
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • rRNA pseudouridine synthesis
  • RNA binding
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • PWP1
  • nucleus
  • cytoplasm
  • nucleolus
  • rRNA processing
  • molecular_function
  • RAD53
  • nucleus
  • DNA replication initiation
  • DNA repair
  • deoxyribonucleoside triphosphate biosynthetic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • DNA replication origin binding
  • protein serine/threonine/tyrosine kinase activity
  • RPC10
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
  • DNA-directed RNA polymerase activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • SEC23
  • cytoplasm
  • COPII vesicle coat
  • ER to Golgi vesicle-mediated transport
  • autophagy
  • ER-associated protein catabolic process
  • GTPase activator activity
  • TAF14
  • SWI/SNF complex
  • transcription factor TFIID complex
  • Ino80 complex
  • transcription factor TFIIF complex
  • histone acetyltransferase complex
  • chromatin remodeling
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • UBI4
  • cytoplasm
  • protein deubiquitination
  • ascospore formation
  • protein polyubiquitination
  • protein monoubiquitination
  • response to stress
  • protein ubiquitination
  • protein tag
  • ATP-dependent protein binding
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • YHB1
  • cytoplasm
  • mitochondrial matrix
  • mitochondrion
  • cytosol
  • response to stress
  • nitric oxide reductase activity
  • YRA1
  • transcription export complex
  • mRNA export from nucleus
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.8338E-9 26 211 10 6292
    nuclear lumen 6.4066E-8 26 453 12 6292
    organelle lumen 4.7239E-7 26 660 13 6292
    intracellular organelle lumen 4.7239E-7 26 660 13 6292
    membrane-enclosed lumen 9.3903E-7 26 700 13 6292
    nucleus 4.0113E-6 26 2041 20 6292
    nuclear part 4.6388E-6 26 1103 15 6292
    non-membrane-bounded organelle 3.3085E-5 26 959 13 6292
    intracellular non-membrane-bounded organelle 3.3085E-5 26 959 13 6292
    Holliday junction resolvase complex 4.9138E-5 26 3 2 6292
    intracellular part 1.8099E-3 26 4938 26 6292
    intracellular 2.1987E-3 26 4975 26 6292
    intracellular organelle part 2.3663E-3 26 2282 17 6292
    organelle part 2.3663E-3 26 2282 17 6292
    membrane-bounded organelle 6.4203E-3 26 3771 22 6292
    intracellular membrane-bounded organelle 6.4203E-3 26 3771 22 6292
    macromolecular complex 7.2942E-3 26 1635 13 6292
    replication fork protection complex 8.248E-3 26 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 5.6257E-6 26 346 9 6292
    ribonucleoprotein complex biogenesis 1.0638E-5 26 374 9 6292
    rRNA metabolic process 1.5361E-5 26 137 6 6292
    cellular component biogenesis 4.4142E-5 26 694 11 6292
    ncRNA metabolic process 5.8975E-5 26 257 7 6292
    rRNA processing 1.5037E-4 26 128 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.5936E-4 26 1566 15 6292
    DNA topological change 4.5282E-4 26 8 2 6292
    nucleic acid metabolic process 4.8106E-4 26 1415 14 6292
    cellular macromolecule metabolic process 6.4593E-4 26 2285 18 6292
    macromolecule metabolic process 9.471E-4 26 2349 18 6292
    cellular process 1.2541E-3 26 4426 25 6292
    cellular nitrogen compound metabolic process 1.4689E-3 26 1770 15 6292
    ncRNA processing 1.6259E-3 26 215 5 6292
    DNA conformation change 1.6627E-3 26 58 3 6292
    nitrogen compound metabolic process 1.6758E-3 26 1791 15 6292
    RNA metabolic process 3.2034E-3 26 954 10 6292
    meiosis I 4.0233E-3 26 79 3 6292
    histone H3-K79 methylation 4.1322E-3 26 1 1 6292
    primary metabolic process 4.7436E-3 26 2896 19 6292
    DNA repair 7.4204E-3 26 192 4 6292
    deoxyribonucleoside triphosphate biosynthetic process 8.248E-3 26 2 1 6292
    histone lysine methylation 8.248E-3 26 2 1 6292
    meiotic prophase I 8.248E-3 26 2 1 6292
    interspecies interaction between organisms 8.248E-3 26 2 1 6292
    meiotic cell cycle checkpoint 8.248E-3 26 2 1 6292
    prophase 8.248E-3 26 2 1 6292
    meiotic recombination checkpoint 8.248E-3 26 2 1 6292
    cellular metabolic process 8.8641E-3 26 3033 19 6292
    gene expression 9.0486E-3 26 1283 11 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    crossover junction endodeoxyribonuclease activity 4.9138E-5 26 3 2 6292
    endodeoxyribonuclease activity, producing 3'-phosphomonoesters 9.8027E-5 26 4 2 6292
    endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 5.8072E-4 26 9 2 6292
    nucleic acid binding 9.381E-4 26 666 9 6292
    binding 2.9404E-3 26 1294 12 6292
    RNA binding 3.2099E-3 26 367 6 6292
    endodeoxyribonuclease activity 3.6053E-3 26 22 2 6292
    nitric oxide reductase activity 4.1322E-3 26 1 1 6292
    7S RNA binding 4.1322E-3 26 1 1 6292
    ATP-dependent protein binding 4.1322E-3 26 1 1 6292
    oxidoreductase activity, acting on other nitrogenous compounds as donors 4.1322E-3 26 1 1 6292
    deoxyribonuclease activity 6.2251E-3 26 29 2 6292
    methionine-tRNA ligase activity 8.248E-3 26 2 1 6292
    5S rRNA binding 8.248E-3 26 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle