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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rpc40. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 35 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACC1
  • endoplasmic reticulum membrane
  • mitochondrion
  • cytosol
  • nuclear envelope organization
  • protein import into nucleus
  • fatty acid biosynthetic process
  • acetyl-CoA carboxylase activity
  • biotin carboxylase activity
  • ACH1
  • mitochondrion
  • cytosol
  • acetate metabolic process
  • acetyl-CoA metabolic process
  • acetyl-CoA hydrolase activity
  • ADH2
  • cytoplasm
  • fermentation
  • ethanol metabolic process
  • NADH oxidation
  • alcohol dehydrogenase (NAD) activity
  • ADR1
  • nucleus
  • regulation of carbohydrate metabolic process
  • transcription
  • peroxisome organization
  • negative regulation of transcription from RNA polymerase II promoter by glucose
  • transcription factor activity
  • GCD11
  • multi-eIF complex
  • ribosome
  • eukaryotic translation initiation factor 2 complex
  • translational initiation
  • translation initiation factor activity
  • GFA1
  • cellular_component
  • cell wall chitin biosynthetic process
  • glutamine-fructose-6-phosphate transaminase (isomerizing) activity
  • GND1
  • cytoplasm
  • mitochondrion
  • response to oxidative stress
  • pentose-phosphate shunt, oxidative branch
  • phosphogluconate dehydrogenase (decarboxylating) activity
  • GUS1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • glutamyl-tRNA aminoacylation
  • glutamate-tRNA ligase activity
  • IDH2
  • mitochondrial matrix
  • mitochondrion
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • ISA2
  • mitochondrial intermembrane space
  • mitochondrion
  • iron ion transport
  • response to drug
  • biotin biosynthetic process
  • molecular_function
  • MDH1
  • mitochondrial matrix
  • mitochondrion
  • malate metabolic process
  • tricarboxylic acid cycle
  • L-malate dehydrogenase activity
  • MET18
  • nucleoplasm
  • telomere maintenance
  • nucleotide-excision repair
  • transcription from RNA polymerase II promoter
  • methionine metabolic process
  • RNA polymerase II transcription factor activity
  • NGL2
  • intracellular
  • rRNA processing
  • endoribonuclease activity
  • PYC1
  • cytosol
  • gluconeogenesis
  • NADPH regeneration
  • pyruvate carboxylase activity
  • PYC2
  • cytosol
  • gluconeogenesis
  • NADPH regeneration
  • pyruvate carboxylase activity
  • RET1
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • RPA135
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPA190
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • DNA-directed RNA polymerase activity
  • RPA49
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • regulation of cell size
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPB5
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
  • DNA-directed RNA polymerase activity
  • RPC19
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPC25
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • RPC34
  • nucleus
  • cytoplasm
  • mitochondrion
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPC40
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPC82
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPO26
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
  • DNA-directed RNA polymerase activity
  • RPO31
  • DNA-directed RNA polymerase III complex
  • transcription from RNA polymerase III promoter
  • DNA-directed RNA polymerase activity
  • RVS167
  • actin cortical patch
  • vesicle-mediated transport
  • bipolar cellular bud site selection
  • response to osmotic stress
  • endocytosis
  • cytoskeletal protein binding
  • SEC27
  • COPI vesicle coat
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • molecular_function
  • TBS1
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • molecular_function
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • TSA2
  • cytoplasm
  • response to oxidative stress
  • thioredoxin peroxidase activity
  • peroxiredoxin activity
  • YFL042C
  • cellular_component
  • biological_process
  • molecular_function
  • YHR112C
  • cytoplasm
  • sulfur metabolic process
  • cystathionine beta-lyase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase complex 1.3882E-20 35 31 12 6292
    DNA-directed RNA polymerase complex 1.3882E-20 35 31 12 6292
    nuclear DNA-directed RNA polymerase complex 1.3882E-20 35 31 12 6292
    DNA-directed RNA polymerase III complex 3.9338E-17 35 17 9 6292
    DNA-directed RNA polymerase I complex 2.9086E-13 35 14 7 6292
    nucleolar part 3.4067E-9 35 45 7 6292
    membrane-enclosed lumen 2.4663E-7 35 700 16 6292
    nuclear lumen 4.0075E-7 35 453 13 6292
    organelle lumen 7.6452E-7 35 660 15 6292
    intracellular organelle lumen 7.6452E-7 35 660 15 6292
    nucleoplasm 1.0339E-6 35 264 10 6292
    nucleoplasm part 5.1637E-6 35 245 9 6292
    protein complex 3.5223E-5 35 1137 17 6292
    nucleolus 1.3038E-4 35 211 7 6292
    DNA-directed RNA polymerase II, core complex 1.916E-3 35 12 2 6292
    macromolecular complex 3.3177E-3 35 1635 17 6292
    nuclear part 4.4973E-3 35 1103 13 6292
    intracellular organelle part 9.3065E-3 35 2282 20 6292
    organelle part 9.3065E-3 35 2282 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase III promoter 2.4387E-13 35 38 9 6292
    transcription from RNA polymerase I promoter 1.6207E-10 35 30 7 6292
    transcription, DNA-dependent 1.7564E-7 35 503 14 6292
    RNA biosynthetic process 1.9874E-7 35 508 14 6292
    transcription 5.5656E-7 35 552 14 6292
    nitrogen compound metabolic process 9.3841E-7 35 1791 24 6292
    cofactor metabolic process 1.442E-6 35 154 8 6292
    cellular biosynthetic process 2.1211E-6 35 1567 22 6292
    biosynthetic process 3.161E-6 35 1602 22 6292
    coenzyme metabolic process 3.3261E-6 35 120 7 6292
    cellular nitrogen compound metabolic process 3.9291E-6 35 1770 23 6292
    cellular metabolic process 4.1682E-6 35 3033 30 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0332E-5 35 1566 21 6292
    metabolic process 1.164E-5 35 3157 30 6292
    RNA metabolic process 1.6178E-5 35 954 16 6292
    organic acid metabolic process 6.0658E-5 35 333 9 6292
    oxoacid metabolic process 6.0658E-5 35 333 9 6292
    carboxylic acid metabolic process 6.0658E-5 35 333 9 6292
    cellular macromolecule biosynthetic process 6.2617E-5 35 1187 17 6292
    macromolecule biosynthetic process 6.4031E-5 35 1189 17 6292
    NADPH regeneration 6.8549E-5 35 15 3 6292
    cellular ketone metabolic process 8.1766E-5 35 346 9 6292
    nicotinamide nucleotide metabolic process 8.4905E-5 35 43 4 6292
    pyridine nucleotide metabolic process 1.1095E-4 35 46 4 6292
    NADP metabolic process 1.2154E-4 35 18 3 6292
    acetyl-CoA metabolic process 1.685E-4 35 20 3 6292
    gene expression 1.7318E-4 35 1283 17 6292
    oxidoreduction coenzyme metabolic process 2.9397E-4 35 59 4 6292
    nucleic acid metabolic process 5.9594E-4 35 1415 17 6292
    primary metabolic process 6.3131E-4 35 2896 26 6292
    monocarboxylic acid metabolic process 7.8964E-4 35 134 5 6292
    small molecule metabolic process 1.9974E-3 35 760 11 6292
    ribosome biogenesis 2.5263E-3 35 346 7 6292
    cellular process 2.6951E-3 35 4426 32 6292
    tricarboxylic acid cycle 3.0164E-3 35 15 2 6292
    acetyl-CoA catabolic process 3.0164E-3 35 15 2 6292
    ribonucleoprotein complex biogenesis 3.9121E-3 35 374 7 6292
    nucleotide metabolic process 5.2515E-3 35 128 4 6292
    nucleoside phosphate metabolic process 5.2515E-3 35 128 4 6292
    coenzyme catabolic process 5.3639E-3 35 20 2 6292
    cofactor catabolic process 6.4761E-3 35 22 2 6292
    cellular carbohydrate biosynthetic process 9.0207E-3 35 78 3 6292
    cellular macromolecule metabolic process 9.4596E-3 35 2285 20 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase activity 5.3394E-20 35 34 12 6292
    DNA-directed RNA polymerase activity 5.3394E-20 35 34 12 6292
    nucleotidyltransferase activity 4.3435E-11 35 168 12 6292
    ligase activity, forming carbon-carbon bonds 6.2849E-7 35 4 3 6292
    transferase activity, transferring phosphorus-containing groups 1.3635E-6 35 420 12 6292
    catalytic activity 1.3808E-6 35 2150 26 6292
    pyruvate carboxylase activity 3.0063E-5 35 2 2 6292
    transferase activity 1.9818E-4 35 797 13 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6.6527E-4 35 73 4 6292
    oxidoreductase activity, acting on CH-OH group of donors 9.8536E-4 35 81 4 6292
    biotin carboxylase activity 5.5626E-3 35 1 1 6292
    glutamine-fructose-6-phosphate transaminase (isomerizing) activity 5.5626E-3 35 1 1 6292
    acetyl-CoA hydrolase activity 5.5626E-3 35 1 1 6292
    ligase activity 9.1482E-3 35 150 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle