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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Ess1. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BCY1
  • nucleus
  • cytoplasm
  • response to heat
  • signal transduction
  • pseudohyphal growth
  • response to stress
  • cAMP-dependent protein kinase inhibitor activity
  • CAR2
  • nucleus
  • cytoplasm
  • arginine catabolic process
  • ornithine-oxo-acid transaminase activity
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • ESS1
  • nucleus
  • negative regulation of transcription from RNA polymerase II promoter
  • mRNA processing
  • termination of RNA polymerase II transcription
  • negative regulation of phosphorylation
  • transcription elongation regulator activity
  • peptidyl-prolyl cis-trans isomerase activity
  • HEF3
  • cytosolic ribosome
  • translational elongation
  • ATPase activity
  • translation elongation factor activity
  • HSP104
  • nucleus
  • cytoplasm
  • telomere maintenance
  • chaperone mediated protein folding requiring cofactor
  • protein refolding
  • response to stress
  • chaperone binding
  • ATPase activity, coupled
  • HXT6
  • mitochondrion
  • plasma membrane
  • hexose transport
  • fructose transmembrane transporter activity
  • glucose transmembrane transporter activity
  • mannose transmembrane transporter activity
  • MDN1
  • nucleus
  • mitochondrion
  • nucleoplasm
  • protein complex assembly
  • rRNA processing
  • ribosomal large subunit assembly
  • ATPase activity
  • PUP2
  • proteasome core complex, alpha-subunit complex
  • ascospore formation
  • response to stress
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPB3
  • DNA-directed RNA polymerase II, core complex
  • transcription from RNA polymerase II promoter
  • DNA-directed RNA polymerase activity
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPO21
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
  • transcription from RNA polymerase II promoter
  • DNA-directed RNA polymerase activity
  • SPT5
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • mitochondrion
  • regulation of transcription, DNA-dependent
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
  • RNA polymerase II transcription elongation factor activity
  • TFG1
  • transcription factor TFIIF complex
  • transcription initiation from RNA polymerase II promoter
  • general RNA polymerase II transcription factor activity
  • TOM1
  • nucleus
  • nucleolus
  • nucleocytoplasmic transport
  • protein polyubiquitination
  • regulation of cell size
  • mitosis
  • protein monoubiquitination
  • nucleus organization
  • ubiquitin-protein ligase activity
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • YHR033W
  • cytoplasm
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear lumen 9.8647E-5 17 453 7 6292
    DNA-directed RNA polymerase II, holoenzyme 4.1574E-4 17 56 3 6292
    DNA-directed RNA polymerase II, core complex 4.4637E-4 17 12 2 6292
    nucleoplasm 5.1126E-4 17 264 5 6292
    organelle lumen 1.0252E-3 17 660 7 6292
    intracellular organelle lumen 1.0252E-3 17 660 7 6292
    nucleus 1.4135E-3 17 2041 12 6292
    membrane-enclosed lumen 1.4596E-3 17 700 7 6292
    DNA-directed RNA polymerase complex 3.0514E-3 17 31 2 6292
    RNA polymerase complex 3.0514E-3 17 31 2 6292
    nuclear DNA-directed RNA polymerase complex 3.0514E-3 17 31 2 6292
    nucleoplasm part 3.5752E-3 17 245 4 6292
    DSIF complex 5.3968E-3 17 2 1 6292
    proteasome complex 7.2051E-3 17 48 2 6292
    transcription factor TFIIF complex 8.0849E-3 17 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cellular macromolecule metabolic process 8.7181E-4 17 2285 13 6292
    macromolecule metabolic process 1.1807E-3 17 2349 13 6292
    transcription from RNA polymerase II promoter 1.5101E-3 17 335 5 6292
    primary metabolic process 2.4078E-3 17 2896 14 6292
    'de novo' posttranslational protein folding 2.7018E-3 17 1 1 6292
    chaperone mediated protein folding requiring cofactor 2.7018E-3 17 1 1 6292
    chaperone-mediated protein folding 2.7018E-3 17 1 1 6292
    cellular metabolic process 4.1361E-3 17 3033 14 6292
    arginine catabolic process 5.3968E-3 17 2 1 6292
    metabolic process 6.562E-3 17 3157 14 6292
    RNA metabolic process 8.6957E-3 17 954 7 6292
    transcription, DNA-dependent 8.8228E-3 17 503 5 6292
    RNA biosynthetic process 9.1953E-3 17 508 5 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cis-trans isomerase activity 6.135E-4 17 14 2 6292
    peptidyl-prolyl cis-trans isomerase activity 6.135E-4 17 14 2 6292
    transcription elongation regulator activity 1.1437E-3 17 19 2 6292
    cAMP-dependent protein kinase inhibitor activity 2.7018E-3 17 1 1 6292
    ornithine-oxo-acid transaminase activity 2.7018E-3 17 1 1 6292
    RNA polymerase activity 3.6639E-3 17 34 2 6292
    DNA-directed RNA polymerase activity 3.6639E-3 17 34 2 6292
    endopeptidase activity 9.0541E-3 17 54 2 6292
    catalytic activity 9.7716E-3 17 2150 11 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle