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View Protein Complex Details

Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARX1
  • cytoplasm
  • nucleoplasm
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • BEM2
  • mitochondrion
  • intracellular
  • small GTPase mediated signal transduction
  • cellular cell wall organization
  • microtubule cytoskeleton organization
  • budding cell bud growth
  • actin cytoskeleton organization
  • Rho GTPase activator activity
  • signal transducer activity
  • BMS1
  • nucleus
  • cytoplasm
  • mitochondrion
  • nuclear outer membrane
  • nucleolus
  • ribosome assembly
  • rRNA processing
  • GTP binding
  • BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • BUD20
  • nucleus
  • cellular bud site selection
  • ribosome biogenesis
  • molecular_function
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • CYR1
  • mitochondrion
  • plasma membrane
  • G-protein signaling, coupled to cAMP nucleotide second messenger
  • Ras protein signal transduction
  • age-dependent response to oxidative stress involved in chronological cell aging
  • meiosis
  • adenylate cyclase activity
  • CYS4
  • cytoplasm
  • mitochondrion
  • response to drug
  • cysteine biosynthetic process
  • cystathionine beta-synthase activity
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DBP9
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DCP2
  • nucleus
  • cytoplasm
  • cytoplasmic mRNA processing body
  • deadenylation-independent decapping of nuclear-transcribed mRNA
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • mRNA catabolic process
  • mRNA binding
  • m7G(5')pppN diphosphatase activity
  • hydrolase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • EBP2
  • nucleolus
  • nuclear division
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • FPR4
  • nucleus
  • chromatin
  • chromatin silencing at rDNA
  • negative regulation of histone H3-K36 methylation
  • ribosome biogenesis
  • histone peptidyl-prolyl isomerization
  • positive regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly
  • peptidyl-prolyl cis-trans isomerase activity
  • histone binding
  • GCN1
  • mitochondrion
  • cytosol
  • regulation of translational elongation
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • HDA1
  • histone deacetylase complex
  • loss of chromatin silencing involved in replicative cell aging
  • regulation of transcription, DNA-dependent
  • protein amino acid deacetylation
  • chromatin organization
  • histone deacetylase activity
  • HER1
  • cytoplasm
  • mitochondrion
  • ribosome
  • biological_process
  • molecular_function
  • HIS3
  • cellular_component
  • histidine biosynthetic process
  • imidazoleglycerol-phosphate dehydratase activity
  • INP2
  • peroxisome
  • integral to peroxisomal membrane
  • cytoplasm
  • peroxisome inheritance
  • protein anchor
  • IPI1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • IPI3
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • LHP1
  • nucleus
  • nucleolus
  • nucleoplasm
  • tRNA processing
  • RNA binding
  • LOC1
  • nucleus
  • intracellular mRNA localization
  • ribosomal large subunit biogenesis
  • mRNA binding
  • LSG1
  • cytoplasm
  • ascospore formation
  • ribosomal subunit export from nucleus
  • conjugation with cellular fusion
  • ribosome biogenesis
  • GTPase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • MAK5
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • MDN1
  • nucleus
  • mitochondrion
  • nucleoplasm
  • protein complex assembly
  • rRNA processing
  • ribosomal large subunit assembly
  • ATPase activity
  • MIS1
  • mitochondrion
  • ribosome biogenesis
  • folic acid biosynthetic process
  • anaerobic purine catabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • acetate biosynthetic process from carbon monoxide
  • formate-tetrahydrofolate ligase activity
  • methenyltetrahydrofolate cyclohydrolase activity
  • methylenetetrahydrofolate dehydrogenase (NADP+) activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NAP1
  • nucleus
  • cytoplasm
  • nuclear nucleosome
  • M phase of mitotic cell cycle
  • budding cell bud growth
  • nucleosome assembly
  • histone binding
  • NIP1
  • multi-eIF complex
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NMD3
  • cytosol
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • RNA binding
  • protein binding
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOG2
  • nucleus
  • nucleolus
  • nucleoplasm
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • GTPase activity
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP16
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NOP56
  • box C/D snoRNP complex
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PRT1
  • multi-eIF complex
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • REI1
  • cytoplasm
  • nucleocytoplasmic transport
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • budding cell bud growth
  • mitotic cell cycle
  • molecular_function
  • RIX1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RIX7
  • nucleus
  • nucleolus
  • ribosomal large subunit export from nucleus
  • ATPase activity
  • RLP24
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPA135
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
  • DNA-directed RNA polymerase activity
  • RPA190
  • DNA-directed RNA polymerase I complex
  • transcription from RNA polymerase I promoter
  • DNA-directed RNA polymerase activity
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RPG1
  • incipient cellular bud site
  • cytoplasm
  • ribosome
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • translation initiation factor activity
  • RPP2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translational elongation
  • translation
  • structural constituent of ribosome
  • RPT6
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RRP1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • RRP12
  • nucleus
  • ribosome
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • RSA3
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal large subunit assembly
  • molecular_function
  • RSA4
  • nucleolus
  • ribosome
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RTR1
  • cytoplasm
  • biological_process
  • molecular_function
  • SDA1
  • nucleus
  • ribosome biogenesis
  • traversing start control point of mitotic cell cycle
  • ribosome assembly
  • actin cytoskeleton organization
  • molecular_function
  • SEC7
  • late endosome
  • cytosol
  • Golgi-associated vesicle
  • ER to Golgi vesicle-mediated transport
  • intra-Golgi vesicle-mediated transport
  • ARF guanyl-nucleotide exchange factor activity
  • SKI2
  • cytoplasm
  • nucleolus
  • regulation of translation
  • response to exogenous dsRNA
  • mRNA catabolic process
  • RNA helicase activity
  • translation repressor activity
  • SNU13
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • SPB1
  • nucleus
  • nucleolus
  • rRNA methylation
  • processing of 27S pre-rRNA
  • rRNA (uridine-2'-O-)-methyltransferase activity
  • rRNA (guanine) methyltransferase activity
  • SPB4
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • SSF1
  • nucleolus
  • conjugation with cellular fusion
  • regulation of cell size
  • ribosomal large subunit assembly
  • rRNA binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • TUB3
  • tubulin complex
  • kinetochore microtubule
  • spindle pole body
  • polar microtubule
  • nuclear microtubule
  • cytoplasmic microtubule
  • homologous chromosome segregation
  • mitotic sister chromatid segregation
  • nuclear migration along microtubule
  • nuclear migration during conjugation with cellular fusion
  • structural constituent of cytoskeleton
  • URB1
  • nucleolus
  • rRNA processing
  • processing of 27S pre-rRNA
  • molecular_function
  • UTP10
  • mitochondrion
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP20
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
  • snoRNA binding
  • UTP22
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • YGL036W
  • cytoplasm
  • biological_process
  • molecular_function
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 3.4924E-53 86 211 50 6292
    nuclear lumen 6.9311E-44 86 453 56 6292
    organelle lumen 1.07E-34 86 660 56 6292
    intracellular organelle lumen 1.07E-34 86 660 56 6292
    membrane-enclosed lumen 2.6946E-33 86 700 56 6292
    non-membrane-bounded organelle 5.0273E-27 86 959 57 6292
    intracellular non-membrane-bounded organelle 5.0273E-27 86 959 57 6292
    nuclear part 8.4677E-25 86 1103 58 6292
    nucleus 2.6483E-17 86 2041 66 6292
    nuclear outer membrane 5.4921E-12 86 86 14 6292
    intracellular organelle part 1.1247E-11 86 2282 62 6292
    organelle part 1.1247E-11 86 2282 62 6292
    nuclear membrane 3.0038E-11 86 97 14 6292
    preribosome, large subunit precursor 4.4449E-10 86 9 6 6292
    intracellular part 1.8946E-8 86 4938 85 6292
    membrane-bounded organelle 2.3306E-8 86 3771 75 6292
    intracellular membrane-bounded organelle 2.3306E-8 86 3771 75 6292
    intracellular 3.4997E-8 86 4975 85 6292
    nuclear envelope 5.6401E-8 86 199 15 6292
    outer membrane 9.6723E-8 86 178 14 6292
    organelle outer membrane 9.6723E-8 86 178 14 6292
    intracellular organelle 1.1386E-7 86 4070 77 6292
    organelle 1.1561E-7 86 4071 77 6292
    eukaryotic translation initiation factor 3 complex 1.1039E-6 86 7 4 6292
    nuclear membrane-endoplasmic reticulum network 2.4754E-6 86 232 14 6292
    preribosome 5.4121E-6 86 34 6 6292
    ribonucleoprotein complex 1.3376E-5 86 514 20 6292
    Noc complex 2.4177E-5 86 5 3 6292
    cell part 2.6126E-5 86 5397 85 6292
    cell 2.6913E-5 86 5399 85 6292
    nucleolar part 2.9063E-5 86 45 6 6292
    Noc2p-Noc3p complex 1.8468E-4 86 2 2 6292
    Noc1p-Noc2p complex 1.8468E-4 86 2 2 6292
    endomembrane system 2.7431E-4 86 398 15 6292
    small nucleolar ribonucleoprotein complex 4.1528E-4 86 72 6 6292
    nucleoplasm 3.0201E-3 86 264 10 6292
    envelope 3.152E-3 86 505 15 6292
    organelle envelope 3.152E-3 86 505 15 6292
    multi-eIF complex 4.9014E-3 86 8 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 2.3779E-62 86 346 63 6292
    ribonucleoprotein complex biogenesis 4.644E-60 86 374 63 6292
    ribosomal large subunit biogenesis 6.0174E-49 86 65 34 6292
    cellular component biogenesis 6.1443E-44 86 694 64 6292
    ribosome assembly 9.2772E-30 86 64 24 6292
    organelle assembly 8.134E-29 86 69 24 6292
    ribosomal large subunit assembly 8.8752E-26 86 41 19 6292
    ribonucleoprotein complex assembly 2.2859E-25 86 92 24 6292
    ribosomal subunit assembly 8.8192E-23 86 55 19 6292
    rRNA metabolic process 3.0397E-22 86 137 25 6292
    rRNA processing 1.2055E-21 86 128 24 6292
    cellular macromolecular complex assembly 2.6621E-20 86 182 26 6292
    ncRNA processing 2.7126E-17 86 215 25 6292
    ncRNA metabolic process 1.81E-16 86 257 26 6292
    cellular macromolecular complex subunit organization 2.195E-16 86 259 26 6292
    macromolecular complex assembly 1.6441E-15 86 281 26 6292
    macromolecular complex subunit organization 5.1671E-13 86 357 26 6292
    cellular component assembly 3.0038E-12 86 385 26 6292
    RNA processing 1.5733E-11 86 380 25 6292
    cellular process 5.0027E-10 86 4426 83 6292
    processing of 27S pre-rRNA 7.2077E-10 86 16 7 6292
    ribosomal subunit export from nucleus 1.1193E-9 86 26 8 6292
    establishment of ribosome localization 1.1193E-9 86 26 8 6292
    ribosome localization 1.1193E-9 86 26 8 6292
    establishment of organelle localization 4.1439E-8 86 55 9 6292
    RNA metabolic process 1.066E-7 86 954 33 6292
    maturation of SSU-rRNA 1.1017E-6 86 59 8 6292
    gene expression 1.403E-6 86 1283 37 6292
    organelle localization 1.9229E-6 86 85 9 6292
    organelle organization 5.3489E-6 86 1127 33 6292
    obsolete_biological_process 1.4967E-5 86 60 7 6292
    nuclear transport 6.2363E-5 86 130 9 6292
    nucleocytoplasmic transport 6.2363E-5 86 130 9 6292
    nuclear export 7.2521E-5 86 103 8 6292
    ribosomal large subunit export from nucleus 1.9518E-4 86 9 3 6292
    nucleic acid metabolic process 6.0017E-4 86 1415 33 6292
    rRNA modification 1.7345E-3 86 18 3 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.8081E-3 86 1566 34 6292
    cellular component organization 2.1723E-3 86 1582 34 6292
    translational initiation 2.4516E-3 86 42 4 6292
    cellular nitrogen compound metabolic process 4.0821E-3 86 1770 36 6292
    nitrogen compound metabolic process 5.0397E-3 86 1791 36 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA helicase activity 1.2753E-6 86 42 7 6292
    ATP-dependent RNA helicase activity 1.6189E-6 86 28 6 6292
    rRNA binding 1.6466E-6 86 16 5 6292
    RNA-dependent ATPase activity 2.019E-6 86 29 6 6292
    RNA binding 7.0282E-6 86 367 17 6292
    purine NTP-dependent helicase activity 4.2375E-5 86 48 6 6292
    ATP-dependent helicase activity 4.2375E-5 86 48 6 6292
    helicase activity 1.2487E-4 86 83 7 6292
    5S rRNA binding 1.8468E-4 86 2 2 6292
    pyrophosphatase activity 2.6681E-4 86 353 14 6292
    hydrolase activity, acting on acid anhydrides 2.6681E-4 86 353 14 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.6681E-4 86 353 14 6292
    nucleoside-triphosphatase activity 4.6882E-4 86 329 13 6292
    nucleic acid binding 5.0215E-4 86 666 20 6292
    rRNA primary transcript binding 1.7979E-3 86 5 2 6292
    ATPase activity 2.2136E-3 86 211 9 6292
    translation initiation factor activity 5.6904E-3 86 27 3 6292
    binding 5.9103E-3 86 1294 28 6292
    snoRNA binding 8.4084E-3 86 31 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle