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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CSE2
  • nucleus
  • mediator complex
  • mitotic sister chromatid segregation
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • GAL11
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED1
  • nucleus
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED11
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • MED6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • MED8
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • NUT1
  • nucleus
  • mitochondrion
  • regulation of transcription from RNA polymerase II promoter
  • molecular_function
  • NUT2
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • PGD1
  • nucleus
  • mediator complex
  • response to drug
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • RGR1
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SIN4
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB2
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB4
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB5
  • mediator complex
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB6
  • mediator complex
  • transcription from RNA polymerase II promoter
  • structural molecule activity
  • RNA polymerase II transcription mediator activity
  • SRB7
  • nucleus
  • mediator complex
  • transcription from RNA polymerase II promoter
  • RNA polymerase II transcription mediator activity
  • SRB8
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • RNA polymerase II transcription mediator activity
  • SSN2
  • transcription factor complex
  • negative regulation of transcription from RNA polymerase II promoter
  • telomere maintenance
  • general RNA polymerase II transcription factor activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mediator complex 5.235E-43 19 18 16 6292
    nucleoplasm part 4.1982E-25 19 245 18 6292
    nucleoplasm 1.6831E-24 19 264 18 6292
    nuclear lumen 3.4896E-20 19 453 18 6292
    organelle lumen 3.2889E-17 19 660 18 6292
    intracellular organelle lumen 3.2889E-17 19 660 18 6292
    membrane-enclosed lumen 9.5492E-17 19 700 18 6292
    nuclear part 3.4611E-13 19 1103 18 6292
    protein complex 5.9661E-13 19 1137 18 6292
    macromolecular complex 3.9092E-10 19 1635 18 6292
    nucleus 4.8456E-10 19 2041 19 6292
    organelle part 1.4123E-7 19 2282 18 6292
    intracellular organelle part 1.4123E-7 19 2282 18 6292
    membrane-bounded organelle 5.8584E-5 19 3771 19 6292
    intracellular membrane-bounded organelle 5.8584E-5 19 3771 19 6292
    intracellular organelle 2.5052E-4 19 4070 19 6292
    organelle 2.517E-4 19 4071 19 6292
    intracellular part 9.9367E-3 19 4938 19 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    transcription from RNA polymerase II promoter 3.8441E-25 19 335 19 6292
    transcription, DNA-dependent 1.0355E-21 19 503 19 6292
    RNA biosynthetic process 1.2538E-21 19 508 19 6292
    transcription 6.2461E-21 19 552 19 6292
    RNA metabolic process 2.3329E-16 19 954 19 6292
    cellular macromolecule biosynthetic process 1.5364E-14 19 1187 19 6292
    macromolecule biosynthetic process 1.5867E-14 19 1189 19 6292
    gene expression 6.8073E-14 19 1283 19 6292
    nucleic acid metabolic process 4.4309E-13 19 1415 19 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.078E-12 19 1566 19 6292
    cellular biosynthetic process 3.1157E-12 19 1567 19 6292
    biosynthetic process 4.752E-12 19 1602 19 6292
    cellular nitrogen compound metabolic process 3.1931E-11 19 1770 19 6292
    nitrogen compound metabolic process 3.9998E-11 19 1791 19 6292
    cellular macromolecule metabolic process 4.1791E-9 19 2285 19 6292
    macromolecule metabolic process 7.078E-9 19 2349 19 6292
    primary metabolic process 3.8309E-7 19 2896 19 6292
    cellular metabolic process 9.2442E-7 19 3033 19 6292
    metabolic process 1.9837E-6 19 3157 19 6292
    anatomical structure homeostasis 1.1717E-5 19 286 7 6292
    telomere organization 1.1717E-5 19 286 7 6292
    telomere maintenance 1.1717E-5 19 286 7 6292
    chromosome organization 1.0954E-4 19 555 8 6292
    homeostatic process 1.1653E-4 19 408 7 6292
    regulation of biological quality 7.5185E-4 19 551 7 6292
    DNA metabolic process 1.0785E-3 19 585 7 6292
    cellular process 1.2366E-3 19 4426 19 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA polymerase II transcription mediator activity 4.3044E-44 19 22 17 6292
    general RNA polymerase II transcription factor activity 1.8662E-36 19 64 18 6292
    RNA polymerase II transcription factor activity 2.6239E-30 19 130 18 6292
    transcription regulator activity 1.7127E-22 19 339 18 6292

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