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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature. 2006 Mar 30;440(7084):631-6. Epub 2006 Jan 22.
Notes: From the published set of protein complexes (core proteins only)
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ECM29
  • nucleus
  • cytoplasm
  • proteasome complex
  • protein catabolic process
  • protein binding
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN13
  • proteasome regulatory particle, lid subcomplex
  • proteolysis
  • endopeptidase activity
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 1.0659E-27 12 23 11 6292
    proteasome regulatory particle 1.0659E-27 12 23 11 6292
    proteasome complex 8.7593E-27 12 48 12 6292
    proteasome regulatory particle, lid subcomplex 3.6683E-22 12 10 8 6292
    protein complex 1.1559E-9 12 1137 12 6292
    macromolecular complex 9.1989E-8 12 1635 12 6292
    proteasome regulatory particle, base subcomplex 4.4248E-7 12 9 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 1.4832E-16 12 188 11 6292
    protein catabolic process 1.5746E-16 12 189 11 6292
    ubiquitin-dependent protein catabolic process 4.1645E-15 12 156 10 6292
    modification-dependent protein catabolic process 4.1645E-15 12 156 10 6292
    proteolysis involved in cellular protein catabolic process 5.0625E-15 12 159 10 6292
    modification-dependent macromolecule catabolic process 6.9517E-15 12 164 10 6292
    cellular protein catabolic process 1.0661E-14 12 171 10 6292
    macromolecule catabolic process 2.2263E-14 12 294 11 6292
    cellular macromolecule catabolic process 9.1185E-13 12 265 10 6292
    catabolic process 7.3488E-12 12 496 11 6292
    cellular catabolic process 8.2289E-11 12 415 10 6292
    protein metabolic process 1.1437E-9 12 1136 12 6292
    cellular protein metabolic process 9.5815E-7 12 1074 10 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    cellular macromolecule metabolic process 1.1724E-3 12 2285 10 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 2.6685E-10 12 54 6 6292
    peptidase activity, acting on L-amino acid peptides 8.6811E-9 12 95 6 6292
    peptidase activity 5.9245E-7 12 192 6 6292
    hydrolase activity 3.8316E-3 12 911 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle