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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 24 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARP7
  • nucleus
  • SWI/SNF complex
  • RSC complex
  • ATP-dependent chromatin remodeling
  • DNA-dependent ATPase activity
  • general RNA polymerase II transcription factor activity
  • ARP9
  • nucleus
  • SWI/SNF complex
  • RSC complex
  • ATP-dependent chromatin remodeling
  • DNA-dependent ATPase activity
  • general RNA polymerase II transcription factor activity
  • ATG16
  • membrane fraction
  • pre-autophagosomal structure
  • autophagy
  • molecular_function
  • CSH1
  • fungal-type vacuole
  • glycosphingolipid biosynthetic process
  • sphingolipid biosynthetic process
  • transferase activity, transferring glycosyl groups
  • mannosyltransferase activity
  • GRS2
  • cytoplasm
  • glycyl-tRNA aminoacylation
  • glycine-tRNA ligase activity
  • HTL1
  • RSC complex
  • chromatin remodeling
  • telomere maintenance
  • response to DNA damage stimulus
  • chromatin binding
  • MGR1
  • mitochondrion
  • i-AAA complex
  • mitochondrial genome maintenance
  • molecular_function
  • NFI1
  • nucleus
  • nuclear chromatin
  • cytoplasm
  • protein sumoylation
  • chromosome condensation
  • telomere maintenance
  • chromosome segregation
  • SUMO ligase activity
  • NPL6
  • nucleus
  • RSC complex
  • chromatin remodeling
  • protein import into nucleus
  • ATP-dependent chromatin remodeling
  • telomere maintenance
  • response to DNA damage stimulus
  • DNA-dependent ATPase activity
  • PCL9
  • cyclin-dependent protein kinase holoenzyme complex
  • cell cycle
  • cyclin-dependent protein kinase regulator activity
  • RIM15
  • nucleus
  • cytoplasm
  • regulation of meiosis
  • protein amino acid phosphorylation
  • age-dependent response to oxidative stress involved in chronological cell aging
  • response to stress
  • protein kinase activity
  • RSC1
  • RSC complex
  • ATP-dependent chromatin remodeling
  • double-strand break repair via nonhomologous end joining
  • DNA-dependent ATPase activity
  • RSC2
  • RSC complex
  • sister chromatid cohesion
  • ATP-dependent chromatin remodeling
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • DNA-dependent ATPase activity
  • RSC3
  • nucleus
  • RSC complex
  • ATP-dependent chromatin remodeling
  • regulation of transcription, DNA-dependent
  • DNA binding
  • DNA-dependent ATPase activity
  • RSC4
  • RSC complex
  • ATP-dependent chromatin remodeling
  • DNA-dependent ATPase activity
  • RSC58
  • RSC complex
  • chromatin remodeling
  • molecular_function
  • RSC6
  • RSC complex
  • ATP-dependent chromatin remodeling
  • DNA-dependent ATPase activity
  • RSC8
  • nucleus
  • RSC complex
  • ATP-dependent chromatin remodeling
  • double-strand break repair via nonhomologous end joining
  • DNA-dependent ATPase activity
  • RSC9
  • RSC complex
  • chromatin remodeling
  • ATP-dependent chromatin remodeling
  • rRNA transcription
  • regulation of transcription from RNA polymerase II promoter
  • DNA-dependent ATPase activity
  • chromatin binding
  • RTT102
  • nucleus
  • SWI/SNF complex
  • RSC complex
  • chromatin remodeling
  • chromosome segregation
  • molecular_function
  • SFH1
  • RSC complex
  • G2/M transition of mitotic cell cycle
  • ATP-dependent chromatin remodeling
  • chromosome segregation
  • chromatin remodeling at centromere
  • double-strand break repair
  • DNA-dependent ATPase activity
  • STH1
  • RSC complex
  • cytoskeleton organization
  • ATP-dependent chromatin remodeling
  • chromosome segregation
  • chromatin remodeling at centromere
  • meiosis
  • double-strand break repair
  • ATPase activity
  • DNA-dependent ATPase activity
  • URC2
  • nucleus
  • cytoplasm
  • biological_process
  • molecular_function
  • YIL177C
  • cellular_component
  • biological_process
  • helicase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RSC complex 2.7918E-35 24 20 15 6292
    chromatin remodeling complex 3.4843E-22 24 99 15 6292
    protein complex 2.0166E-8 24 1137 17 6292
    nuclear part 1.2913E-7 24 1103 16 6292
    macromolecular complex 5.2115E-6 24 1635 17 6292
    SWI/SNF-type complex 1.3604E-5 24 13 3 6292
    SWI/SNF complex 1.3604E-5 24 13 3 6292
    nucleus 2.2874E-5 24 2041 18 6292
    intracellular organelle part 5.9532E-4 24 2282 17 6292
    organelle part 5.9532E-4 24 2282 17 6292
    i-AAA complex 7.6148E-3 24 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    chromatin remodeling 7.4872E-25 24 68 15 6292
    ATP-dependent chromatin remodeling 3.2033E-24 24 26 12 6292
    chromatin modification 1.4175E-18 24 168 15 6292
    chromatin organization 2.5869E-17 24 203 15 6292
    chromosome organization 4.1255E-12 24 555 16 6292
    organelle organization 1.7555E-8 24 1127 17 6292
    double-strand break repair 1.9021E-6 24 57 5 6292
    cellular component organization 3.1922E-6 24 1582 17 6292
    chromatin remodeling at centromere 1.3945E-5 24 2 2 6292
    response to DNA damage stimulus 1.9146E-5 24 236 7 6292
    cellular response to stress 7.2237E-5 24 290 7 6292
    chromosome segregation 1.0039E-4 24 128 5 6292
    double-strand break repair via nonhomologous end joining 1.0617E-4 24 25 3 6292
    non-recombinational repair 2.7006E-4 24 34 3 6292
    response to stress 3.3856E-4 24 497 8 6292
    cellular response to stimulus 3.8483E-4 24 379 7 6292
    DNA repair 6.6518E-4 24 192 5 6292
    DNA metabolic process 1.0181E-3 24 585 8 6292
    response to stimulus 5.7203E-3 24 766 8 6292
    glycyl-tRNA aminoacylation 7.6148E-3 24 2 1 6292
    nucleic acid metabolic process 9.5021E-3 24 1415 11 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    DNA-dependent ATPase activity 1.3823E-19 24 55 12 6292
    ATPase activity, coupled 4.2248E-14 24 149 12 6292
    ATPase activity 2.8148E-12 24 211 12 6292
    nucleoside-triphosphatase activity 2.5654E-11 24 329 13 6292
    hydrolase activity, acting on acid anhydrides 6.2527E-11 24 353 13 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.2527E-11 24 353 13 6292
    pyrophosphatase activity 6.2527E-11 24 353 13 6292
    hydrolase activity 5.9785E-6 24 911 13 6292
    catalytic activity 2.6436E-4 24 2150 17 6292
    chromatin binding 6.8504E-3 24 33 2 6292
    glycine-tRNA ligase activity 7.6148E-3 24 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle