YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
Notes: Complex description from publication: 13. YLR424W and YKR022C mRNA splicing
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CDC40
  • spliceosomal complex
  • nuclear mRNA branch site recognition
  • nuclear mRNA 3'-splice site recognition
  • second spliceosomal transesterification activity
  • CEF1
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • DNA binding
  • first spliceosomal transesterification activity
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • ECM2
  • nucleus
  • cellular cell wall organization
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • NTR2
  • nucleus
  • cytoplasm
  • spliceosomal complex
  • endoplasmic reticulum
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP45
  • nucleus
  • spliceosomal complex
  • positive regulation of transcription from RNA polymerase II promoter
  • nuclear mRNA splicing, via spliceosome
  • transcription activator activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMX3
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 1.4248E-24 20 45 13 6292
    ribonucleoprotein complex 3.2365E-18 20 514 18 6292
    U5 snRNP 1.3333E-12 20 14 6 6292
    nuclear part 2.8943E-12 20 1103 18 6292
    U4/U6 x U5 tri-snRNP complex 3.8872E-10 20 32 6 6292
    macromolecular complex 2.9554E-9 20 1635 18 6292
    nucleus 6.7236E-9 20 2041 19 6292
    small nuclear ribonucleoprotein complex 2.7463E-8 20 63 6 6292
    organelle part 5.3577E-8 20 2282 19 6292
    intracellular organelle part 5.3577E-8 20 2282 19 6292
    U1 snRNP 1.8158E-5 20 17 3 6292
    intracellular organelle 1.6178E-4 20 4070 20 6292
    organelle 1.6258E-4 20 4071 20 6292
    membrane-bounded organelle 5.0591E-4 20 3771 19 6292
    intracellular membrane-bounded organelle 5.0591E-4 20 3771 19 6292
    intracellular part 7.7919E-3 20 4938 20 6292
    intracellular 9.0491E-3 20 4975 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 1.2801E-31 20 99 18 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.5606E-31 20 100 18 6292
    RNA splicing, via transesterification reactions 5.8933E-31 20 107 18 6292
    RNA splicing 3.4605E-29 20 132 18 6292
    mRNA processing 8.4382E-28 20 156 18 6292
    mRNA metabolic process 2.9863E-25 20 213 18 6292
    RNA processing 8.4849E-23 20 380 19 6292
    RNA metabolic process 4.0051E-15 20 954 19 6292
    gene expression 1.1008E-12 20 1283 19 6292
    nucleic acid metabolic process 6.9882E-12 20 1415 19 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.7137E-11 20 1566 19 6292
    cellular nitrogen compound metabolic process 4.6928E-10 20 1770 19 6292
    nitrogen compound metabolic process 5.8528E-10 20 1791 19 6292
    cellular macromolecule metabolic process 5.4899E-8 20 2285 19 6292
    macromolecule metabolic process 9.1608E-8 20 2349 19 6292
    primary metabolic process 4.3236E-6 20 2896 19 6292
    ribonucleoprotein complex assembly 7.8106E-6 20 92 5 6292
    nuclear mRNA 3'-splice site recognition 9.6001E-6 20 2 2 6292
    cellular metabolic process 1.0049E-5 20 3033 19 6292
    metabolic process 2.082E-5 20 3157 19 6292
    spliceosome assembly 2.1745E-5 20 18 3 6292
    mRNA splice site selection 1.4291E-4 20 6 2 6292
    cellular macromolecular complex assembly 2.0867E-4 20 182 5 6292
    spliceosomal conformational changes to generate catalytic conformation 3.4102E-4 20 9 2 6292
    ribonucleoprotein complex biogenesis 8.0445E-4 20 374 6 6292
    cellular macromolecular complex subunit organization 1.0596E-3 20 259 5 6292
    macromolecular complex assembly 1.5279E-3 20 281 5 6292
    regulation of hormone levels 3.1786E-3 20 1 1 6292
    hormone metabolic process 3.1786E-3 20 1 1 6292
    hormone biosynthetic process 3.1786E-3 20 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 3.1786E-3 20 1 1 6292
    auxin biosynthetic process 3.1786E-3 20 1 1 6292
    auxin metabolic process 3.1786E-3 20 1 1 6292
    macromolecular complex subunit organization 4.3653E-3 20 357 5 6292
    cellular component assembly 6.0258E-3 20 385 5 6292
    cis assembly of pre-catalytic spliceosome 6.3477E-3 20 2 1 6292
    cellular process 8.2259E-3 20 4426 19 6292
    generation of catalytic spliceosome for first transesterification step 9.5071E-3 20 3 1 6292
    nuclear mRNA branch site recognition 9.5071E-3 20 3 1 6292
    nuclear mRNA cis splicing, via spliceosome 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U5 snRNA binding 9.6001E-6 20 2 2 6292
    RNA binding 8.6697E-5 20 367 7 6292
    snRNA binding 9.5453E-5 20 5 2 6292
    first spliceosomal transesterification activity 1.4291E-4 20 6 2 6292
    nucleic acid binding 5.9674E-4 20 666 8 6292
    binding 3.1759E-3 20 1294 10 6292
    ATP-dependent RNA helicase activity 3.4533E-3 20 28 2 6292
    RNA-dependent ATPase activity 3.7021E-3 20 29 2 6292
    RNA helicase activity 7.6592E-3 20 42 2 6292
    ATP-dependent helicase activity 9.9207E-3 20 48 2 6292
    purine NTP-dependent helicase activity 9.9207E-3 20 48 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle