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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 360.10.20
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
NAS6
  • proteasome regulatory particle
  • proteolysis
  • molecular_function
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT6
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 9.2403E-49 18 23 18 6292
    proteasome regulatory particle 9.2403E-49 18 23 18 6292
    proteasome complex 2.0073E-40 18 48 18 6292
    proteasome regulatory particle, base subcomplex 1.1481E-24 18 9 9 6292
    proteasome regulatory particle, lid subcomplex 3.2373E-20 18 10 8 6292
    protein complex 3.7785E-14 18 1137 18 6292
    macromolecular complex 2.7221E-11 18 1635 18 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 1.5932E-28 18 188 18 6292
    ubiquitin-dependent protein catabolic process 3.6853E-27 18 156 17 6292
    modification-dependent protein catabolic process 3.6853E-27 18 156 17 6292
    proteolysis involved in cellular protein catabolic process 5.1832E-27 18 159 17 6292
    modification-dependent macromolecule catabolic process 9.0161E-27 18 164 17 6292
    cellular protein catabolic process 1.9008E-26 18 171 17 6292
    protein catabolic process 1.1264E-25 18 189 17 6292
    cellular macromolecule catabolic process 4.3277E-23 18 265 17 6292
    macromolecule catabolic process 2.654E-22 18 294 17 6292
    cellular catabolic process 1.0495E-19 18 415 17 6292
    catabolic process 2.2674E-18 18 496 17 6292
    protein metabolic process 3.7187E-14 18 1136 18 6292
    cellular protein metabolic process 1.2073E-12 18 1074 17 6292
    macromolecule metabolic process 1.9051E-8 18 2349 18 6292
    cellular macromolecule metabolic process 3.7937E-7 18 2285 17 6292
    primary metabolic process 8.3514E-7 18 2896 18 6292
    metabolic process 3.9649E-6 18 3157 18 6292
    cellular metabolic process 3.9339E-5 18 3033 17 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.9182E-19 18 54 11 6292
    peptidase activity, acting on L-amino acid peptides 1.5E-16 18 95 11 6292
    peptidase activity 4.247E-13 18 192 11 6292
    hydrolase activity 6.6296E-6 18 911 11 6292
    ATPase activity 1.7545E-5 18 211 6 6292
    nucleoside-triphosphatase activity 2.1214E-4 18 329 6 6292
    hydrolase activity, acting on acid anhydrides 3.1173E-4 18 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 3.1173E-4 18 353 6 6292
    pyrophosphatase activity 3.1173E-4 18 353 6 6292
    protein binding, bridging 1.4247E-3 18 20 2 6292

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    Created and Maintained by: Michael Riffle