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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
NAS6
  • proteasome regulatory particle
  • proteolysis
  • molecular_function
  • RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • UBP6
  • proteasome regulatory particle
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • URA3
  • cytosol
  • 'de novo' pyrimidine base biosynthetic process
  • pyrimidine base biosynthetic process
  • orotidine-5'-phosphate decarboxylase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 1.0659E-27 12 23 11 6292
    proteasome regulatory particle 1.0659E-27 12 23 11 6292
    proteasome complex 1.7747E-23 12 48 11 6292
    proteasome regulatory particle, lid subcomplex 2.2496E-15 12 10 6 6292
    protein complex 6.4659E-8 12 1137 11 6292
    proteasome regulatory particle, base subcomplex 4.4248E-7 12 9 3 6292
    macromolecular complex 3.2574E-6 12 1635 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 2.805E-14 12 188 10 6292
    modification-dependent protein catabolic process 5.8092E-13 12 156 9 6292
    ubiquitin-dependent protein catabolic process 5.8092E-13 12 156 9 6292
    proteolysis involved in cellular protein catabolic process 6.9176E-13 12 159 9 6292
    modification-dependent macromolecule catabolic process 9.1861E-13 12 164 9 6292
    cellular protein catabolic process 1.3465E-12 12 171 9 6292
    protein catabolic process 3.357E-12 12 189 9 6292
    cellular macromolecule catabolic process 7.1899E-11 12 265 9 6292
    macromolecule catabolic process 1.8321E-10 12 294 9 6292
    cellular catabolic process 4.0021E-9 12 415 9 6292
    catabolic process 1.9467E-8 12 496 9 6292
    protein metabolic process 6.4045E-8 12 1136 11 6292
    cellular protein metabolic process 9.5815E-7 12 1074 10 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    macromolecule metabolic process 1.5296E-4 12 2349 11 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    cellular macromolecule metabolic process 1.1724E-3 12 2285 10 6292
    cellular metabolic process 2.1697E-3 12 3033 11 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    peptidase activity, acting on L-amino acid peptides 2.2008E-5 12 95 4 6292
    endopeptidase activity 1.2449E-4 12 54 3 6292
    peptidase activity 3.4322E-4 12 192 4 6292
    protein binding, bridging 6.2163E-4 12 20 2 6292
    orotidine-5'-phosphate decarboxylase activity 1.9072E-3 12 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle