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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 21 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPN1
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • cytoplasm
  • endoplasmic reticulum
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN10
  • proteasome regulatory particle, base subcomplex
  • proteasome complex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN11
  • nucleus
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN12
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • RPN13
  • proteasome regulatory particle, lid subcomplex
  • proteolysis
  • endopeptidase activity
  • RPN2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • endopeptidase activity
  • protein binding, bridging
  • RPN3
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN5
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN7
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPN8
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • RPN9
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT1
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT2
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT5
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • RPT6
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SEM1
  • nucleus
  • microsome
  • cytosol
  • proteasome regulatory particle, lid subcomplex
  • filamentous growth
  • proteasomal ubiquitin-dependent protein catabolic process
  • telomere maintenance
  • exocytosis
  • ubiquitin-dependent protein catabolic process
  • molecular_function
  • SPG5
  • cellular_component
  • biological_process
  • molecular_function
  • UBP6
  • proteasome regulatory particle
  • protein deubiquitination
  • ubiquitin-specific protease activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteasome accessory complex 9.8564E-54 21 23 20 6292
    proteasome regulatory particle 9.8564E-54 21 23 20 6292
    proteasome complex 9.2788E-44 21 48 20 6292
    proteasome regulatory particle, lid subcomplex 1.3256E-26 21 10 10 6292
    proteasome regulatory particle, base subcomplex 6.9406E-24 21 9 9 6292
    protein complex 2.0945E-14 21 1137 20 6292
    macromolecular complex 2.8646E-11 21 1635 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    proteolysis 8.6073E-28 21 188 19 6292
    modification-dependent protein catabolic process 5.7836E-27 21 156 18 6292
    ubiquitin-dependent protein catabolic process 5.7836E-27 21 156 18 6292
    proteolysis involved in cellular protein catabolic process 8.3022E-27 21 159 18 6292
    modification-dependent macromolecule catabolic process 1.4927E-26 21 164 18 6292
    cellular protein catabolic process 3.2896E-26 21 171 18 6292
    protein catabolic process 2.1652E-25 21 189 18 6292
    cellular macromolecule catabolic process 1.1713E-22 21 265 18 6292
    macromolecule catabolic process 7.9502E-22 21 294 18 6292
    cellular catabolic process 4.3465E-19 21 415 18 6292
    catabolic process 1.1008E-17 21 496 18 6292
    protein metabolic process 2.058E-14 21 1136 20 6292
    cellular protein metabolic process 3.3528E-13 21 1074 19 6292
    macromolecule metabolic process 3.5684E-8 21 2349 20 6292
    cellular macromolecule metabolic process 3.7885E-7 21 2285 19 6292
    primary metabolic process 2.0783E-6 21 2896 20 6292
    metabolic process 1.0912E-5 21 3157 20 6292
    cellular metabolic process 5.7449E-5 21 3033 19 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endopeptidase activity 1.1988E-20 21 54 12 6292
    peptidase activity, acting on L-amino acid peptides 1.6763E-19 21 95 13 6292
    peptidase activity 2.1827E-15 21 192 13 6292
    hydrolase activity 7.4517E-7 21 911 13 6292
    ATPase activity 4.713E-5 21 211 6 6292
    nucleoside-triphosphatase activity 5.4257E-4 21 329 6 6292
    hydrolase activity, acting on acid anhydrides 7.8937E-4 21 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 7.8937E-4 21 353 6 6292
    pyrophosphatase activity 7.8937E-4 21 353 6 6292
    protein binding, bridging 1.9443E-3 21 20 2 6292
    catalytic activity 8.5084E-3 21 2150 13 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle