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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 8 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
HCA4
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ATP-dependent RNA helicase activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL15A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 4.0213E-10 8 101 6 6292
    cytosolic part 1.2751E-9 8 122 6 6292
    cytosolic large ribosomal subunit 3.6467E-9 8 60 5 6292
    ribosomal subunit 1.4893E-8 8 183 6 6292
    large ribosomal subunit 8.0096E-8 8 110 5 6292
    cytosol 2.0832E-7 8 284 6 6292
    ribosome 2.3602E-7 8 290 6 6292
    non-membrane-bounded organelle 2.8409E-7 8 959 8 6292
    intracellular non-membrane-bounded organelle 2.8409E-7 8 959 8 6292
    ribonucleoprotein complex 7.018E-6 8 514 6 6292
    organelle part 2.9704E-4 8 2282 8 6292
    intracellular organelle part 2.9704E-4 8 2282 8 6292
    macromolecular complex 5.1894E-3 8 1635 6 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosomal subunit assembly 3.5652E-7 8 55 4 6292
    ribosome assembly 6.6114E-7 8 64 4 6292
    organelle assembly 8.9725E-7 8 69 4 6292
    translation 1.1072E-6 8 376 6 6292
    ribonucleoprotein complex assembly 2.866E-6 8 92 4 6292
    ribosomal large subunit assembly 1.4063E-5 8 41 3 6292
    ribosome biogenesis 2.3852E-5 8 346 5 6292
    ribonucleoprotein complex biogenesis 3.4865E-5 8 374 5 6292
    cellular macromolecular complex assembly 4.33E-5 8 182 4 6292
    ribosomal large subunit biogenesis 5.6801E-5 8 65 3 6292
    cellular macromolecular complex subunit organization 1.7229E-4 8 259 4 6292
    macromolecular complex assembly 2.3642E-4 8 281 4 6292
    cellular protein metabolic process 4.9998E-4 8 1074 6 6292
    macromolecular complex subunit organization 5.9444E-4 8 357 4 6292
    cellular component biogenesis 6.7771E-4 8 694 5 6292
    protein metabolic process 6.8696E-4 8 1136 6 6292
    cellular component assembly 7.9316E-4 8 385 4 6292
    cellular macromolecule biosynthetic process 8.7999E-4 8 1187 6 6292
    macromolecule biosynthetic process 8.8836E-4 8 1189 6 6292
    gene expression 1.3613E-3 8 1283 6 6292
    regulation of translation 2.1802E-3 8 57 2 6292
    posttranscriptional regulation of gene expression 2.4935E-3 8 61 2 6292
    regulation of cellular protein metabolic process 3.0901E-3 8 68 2 6292
    regulation of protein metabolic process 3.6499E-3 8 74 2 6292
    cellular biosynthetic process 4.1159E-3 8 1567 6 6292
    biosynthetic process 4.6438E-3 8 1602 6 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 3.6119E-8 8 212 6 6292
    structural molecule activity 5.984E-7 8 339 6 6292
    rRNA binding 7.4989E-7 8 16 3 6292
    RNA binding 3.1798E-5 8 367 5 6292
    nucleic acid binding 5.58E-4 8 666 5 6292
    7S RNA binding 1.2715E-3 8 1 1 6292
    5S rRNA binding 2.5415E-3 8 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle