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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 9 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
HCA4
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ATP-dependent RNA helicase activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 7.8116E-12 9 101 7 6292
    cytosolic part 3.0242E-11 9 122 7 6292
    ribosomal subunit 5.3877E-10 9 183 7 6292
    cytosolic large ribosomal subunit 8.1452E-9 9 60 5 6292
    cytosol 1.1829E-8 9 284 7 6292
    ribosome 1.3691E-8 9 290 7 6292
    non-membrane-bounded organelle 4.2994E-8 9 959 9 6292
    intracellular non-membrane-bounded organelle 4.2994E-8 9 959 9 6292
    large ribosomal subunit 1.7771E-7 9 110 5 6292
    ribonucleoprotein complex 7.2713E-7 9 514 7 6292
    organelle part 1.0749E-4 9 2282 9 6292
    intracellular organelle part 1.0749E-4 9 2282 9 6292
    90S preribosome 2.4464E-4 9 17 2 6292
    preribosome 9.9648E-4 9 34 2 6292
    cytosolic small ribosomal subunit 1.245E-3 9 38 2 6292
    macromolecular complex 1.7084E-3 9 1635 7 6292
    small ribosomal subunit 4.5346E-3 9 73 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 8.3629E-8 9 376 7 6292
    ribosomal subunit assembly 6.3758E-7 9 55 4 6292
    ribosome assembly 1.181E-6 9 64 4 6292
    organelle assembly 1.6017E-6 9 69 4 6292
    ribosome biogenesis 1.9334E-6 9 346 6 6292
    ribonucleoprotein complex biogenesis 3.057E-6 9 374 6 6292
    ribonucleoprotein complex assembly 5.1011E-6 9 92 4 6292
    ribosomal large subunit assembly 2.0999E-5 9 41 3 6292
    regulation of translation 5.698E-5 9 57 3 6292
    posttranscriptional regulation of gene expression 6.9885E-5 9 61 3 6292
    cellular macromolecular complex assembly 7.6181E-5 9 182 4 6292
    ribosomal large subunit biogenesis 8.4573E-5 9 65 3 6292
    regulation of cellular protein metabolic process 9.6826E-5 9 68 3 6292
    cellular protein metabolic process 1.0846E-4 9 1074 7 6292
    cellular component biogenesis 1.1047E-4 9 694 6 6292
    regulation of protein metabolic process 1.247E-4 9 74 3 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.4073E-4 9 13 2 6292
    protein metabolic process 1.5759E-4 9 1136 7 6292
    cellular macromolecule biosynthetic process 2.1089E-4 9 1187 7 6292
    macromolecule biosynthetic process 2.1326E-4 9 1189 7 6292
    cellular macromolecular complex subunit organization 3.0012E-4 9 259 4 6292
    gene expression 3.5247E-4 9 1283 7 6292
    macromolecular complex assembly 4.1064E-4 9 281 4 6292
    ribosomal small subunit biogenesis 5.8072E-4 9 26 2 6292
    macromolecular complex subunit organization 1.0223E-3 9 357 4 6292
    cellular biosynthetic process 1.2993E-3 9 1567 7 6292
    cellular component assembly 1.359E-3 9 385 4 6292
    biosynthetic process 1.4983E-3 9 1602 7 6292
    maturation of SSU-rRNA 2.9832E-3 9 59 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.5204E-9 9 212 7 6292
    structural molecule activity 4.0688E-8 9 339 7 6292
    rRNA binding 1.1231E-6 9 16 3 6292
    RNA binding 6.8127E-5 9 367 5 6292
    nucleic acid binding 1.1464E-3 9 666 5 6292
    7S RNA binding 1.4304E-3 9 1 1 6292
    5S rRNA binding 2.859E-3 9 2 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle