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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MRT4
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • telomere maintenance
  • ribosome biogenesis
  • rRNA processing
  • mRNA catabolic process
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOG2
  • nucleus
  • nucleolus
  • nucleoplasm
  • ribosomal large subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • GTPase activity
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA2
  • nucleus
  • preribosome, large subunit precursor
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RIX1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.6598E-18 15 211 13 6292
    nuclear lumen 1.1676E-15 15 453 14 6292
    organelle lumen 2.3378E-13 15 660 14 6292
    intracellular organelle lumen 2.3378E-13 15 660 14 6292
    membrane-enclosed lumen 5.3354E-13 15 700 14 6292
    nuclear part 3.0389E-10 15 1103 14 6292
    non-membrane-bounded organelle 1.7363E-9 15 959 13 6292
    intracellular non-membrane-bounded organelle 1.7363E-9 15 959 13 6292
    nucleus 4.4738E-8 15 2041 15 6292
    organelle part 6.6039E-6 15 2282 14 6292
    intracellular organelle part 6.6039E-6 15 2282 14 6292
    nuclear outer membrane 3.9595E-5 15 86 4 6292
    nuclear membrane 6.3611E-5 15 97 4 6292
    nuclear envelope 6.9785E-5 15 199 5 6292
    preribosome, large subunit precursor 1.8916E-4 15 9 2 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    outer membrane 6.6197E-4 15 178 4 6292
    organelle outer membrane 6.6197E-4 15 178 4 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292
    endomembrane system 1.7459E-3 15 398 5 6292
    nuclear membrane-endoplasmic reticulum network 1.7834E-3 15 232 4 6292
    preribosome 2.8479E-3 15 34 2 6292
    envelope 4.9781E-3 15 505 5 6292
    organelle envelope 4.9781E-3 15 505 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 9.5036E-20 15 346 15 6292
    ribonucleoprotein complex biogenesis 3.1258E-19 15 374 15 6292
    ribosomal large subunit biogenesis 1.9412E-17 15 65 10 6292
    cellular component biogenesis 3.7988E-15 15 694 15 6292
    establishment of ribosome localization 3.0329E-7 15 26 4 6292
    ribosome localization 3.0329E-7 15 26 4 6292
    ribosomal subunit export from nucleus 3.0329E-7 15 26 4 6292
    processing of 27S pre-rRNA 6.027E-6 15 16 3 6292
    establishment of organelle localization 6.6428E-6 15 55 4 6292
    rRNA processing 8.2175E-6 15 128 5 6292
    rRNA metabolic process 1.1464E-5 15 137 5 6292
    ribosome assembly 1.222E-5 15 64 4 6292
    organelle assembly 1.651E-5 15 69 4 6292
    organelle localization 3.7807E-5 15 85 4 6292
    ribonucleoprotein complex assembly 5.1661E-5 15 92 4 6292
    nuclear export 8.0486E-5 15 103 4 6292
    ncRNA processing 1.0091E-4 15 215 5 6292
    nuclear transport 1.9905E-4 15 130 4 6292
    nucleocytoplasmic transport 1.9905E-4 15 130 4 6292
    ncRNA metabolic process 2.3443E-4 15 257 5 6292
    obsolete_biological_process 3.4578E-4 15 60 3 6292
    cellular macromolecular complex assembly 7.1996E-4 15 182 4 6292
    RNA processing 1.4183E-3 15 380 5 6292
    cellular macromolecular complex subunit organization 2.6728E-3 15 259 4 6292
    macromolecular complex assembly 3.5955E-3 15 281 4 6292
    ribosomal large subunit assembly 4.1228E-3 15 41 2 6292
    cellular process 5.0732E-3 15 4426 15 6292
    actomyosin structure organization 7.136E-3 15 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 7.136E-3 15 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 7.136E-3 15 3 1 6292
    ribosomal subunit assembly 7.324E-3 15 55 2 6292
    macromolecular complex subunit organization 8.4401E-3 15 357 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 1.9348E-3 15 28 2 6292
    RNA-dependent ATPase activity 2.0753E-3 15 29 2 6292
    ribosomal large subunit binding 2.384E-3 15 1 1 6292
    RNA helicase activity 4.323E-3 15 42 2 6292
    ATP-dependent helicase activity 5.6171E-3 15 48 2 6292
    purine NTP-dependent helicase activity 5.6171E-3 15 48 2 6292
    nucleoside-triphosphatase activity 6.328E-3 15 329 4 6292
    hydrolase activity, acting on acid anhydrides 8.113E-3 15 353 4 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 8.113E-3 15 353 4 6292
    pyrophosphatase activity 8.113E-3 15 353 4 6292
    GTPase activity 8.9514E-3 15 61 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle