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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • EBP2
  • nucleolus
  • nuclear division
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RPF2
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • 5S rRNA binding
  • 7S RNA binding
  • rRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.4851E-21 14 211 14 6292
    nuclear lumen 8.3271E-17 14 453 14 6292
    organelle lumen 1.7241E-14 14 660 14 6292
    intracellular organelle lumen 1.7241E-14 14 660 14 6292
    membrane-enclosed lumen 3.9609E-14 14 700 14 6292
    non-membrane-bounded organelle 3.3674E-12 14 959 14 6292
    intracellular non-membrane-bounded organelle 3.3674E-12 14 959 14 6292
    nuclear part 2.4173E-11 14 1103 14 6292
    preribosome, large subunit precursor 1.9209E-9 14 9 4 6292
    Noc complex 8.7489E-8 14 5 3 6292
    nucleus 1.3856E-7 14 2041 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    organelle part 6.6422E-7 14 2282 14 6292
    preribosome 6.8484E-7 14 34 4 6292
    Noc2p-Noc3p complex 4.5979E-6 14 2 2 6292
    Noc1p-Noc2p complex 4.5979E-6 14 2 2 6292
    nucleolar part 1.1779E-4 14 45 3 6292
    90S preribosome 6.135E-4 14 17 2 6292
    membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    intracellular membrane-bounded organelle 7.6409E-4 14 3771 14 6292
    nuclear outer membrane 8.0491E-4 14 86 3 6292
    nuclear membrane 1.1429E-3 14 97 3 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    outer membrane 6.4382E-3 14 178 3 6292
    organelle outer membrane 6.4382E-3 14 178 3 6292
    nuclear envelope 8.7658E-3 14 199 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.7971E-18 14 346 14 6292
    ribonucleoprotein complex biogenesis 5.4511E-18 14 374 14 6292
    cellular component biogenesis 3.5072E-14 14 694 14 6292
    ribosomal large subunit biogenesis 2.3805E-13 14 65 8 6292
    ribosome assembly 2.4576E-9 14 64 6 6292
    organelle assembly 3.908E-9 14 69 6 6292
    ribosomal large subunit assembly 1.7515E-8 14 41 5 6292
    ribonucleoprotein complex assembly 2.2665E-8 14 92 6 6292
    ribosomal subunit assembly 7.9952E-8 14 55 5 6292
    cellular macromolecular complex assembly 1.3361E-6 14 182 6 6292
    rRNA processing 5.5689E-6 14 128 5 6292
    rRNA metabolic process 7.7781E-6 14 137 5 6292
    cellular macromolecular complex subunit organization 1.0438E-5 14 259 6 6292
    macromolecular complex assembly 1.6684E-5 14 281 6 6292
    macromolecular complex subunit organization 6.5117E-5 14 357 6 6292
    ncRNA processing 6.9188E-5 14 215 5 6292
    cellular component assembly 9.9527E-5 14 385 6 6292
    ncRNA metabolic process 1.6164E-4 14 257 5 6292
    RNA processing 9.9431E-4 14 380 5 6292
    establishment of ribosome localization 1.4494E-3 14 26 2 6292
    ribosome localization 1.4494E-3 14 26 2 6292
    ribosomal subunit export from nucleus 1.4494E-3 14 26 2 6292
    organelle organization 6.1726E-3 14 1127 7 6292
    establishment of organelle localization 6.383E-3 14 55 2 6292
    cellular process 7.2188E-3 14 4426 14 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    5S rRNA binding 4.5979E-6 14 2 2 6292
    rRNA binding 5.4201E-4 14 16 2 6292
    ATP-dependent RNA helicase activity 1.6815E-3 14 28 2 6292
    RNA-dependent ATPase activity 1.8037E-3 14 29 2 6292
    7S RNA binding 2.225E-3 14 1 1 6292
    RNA helicase activity 3.7625E-3 14 42 2 6292
    ATP-dependent helicase activity 4.8918E-3 14 48 2 6292
    purine NTP-dependent helicase activity 4.8918E-3 14 48 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle