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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 22 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOC3
  • nucleus
  • Noc2p-Noc3p complex
  • nucleolus
  • DNA replication initiation
  • ribosome biogenesis
  • rRNA processing
  • protein binding
  • chromatin binding
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RIX1
  • nucleus
  • nuclear outer membrane
  • nucleoplasm
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • RIX7
  • nucleus
  • nucleolus
  • ribosomal large subunit export from nucleus
  • ATPase activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • SPB4
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 8.5625E-31 22 211 21 6292
    nuclear lumen 4.4846E-26 22 453 22 6292
    organelle lumen 2.084E-22 22 660 22 6292
    intracellular organelle lumen 2.084E-22 22 660 22 6292
    membrane-enclosed lumen 7.7618E-22 22 700 22 6292
    nuclear part 1.9396E-17 22 1103 22 6292
    non-membrane-bounded organelle 1.0911E-16 22 959 21 6292
    intracellular non-membrane-bounded organelle 1.0911E-16 22 959 21 6292
    nucleus 1.6212E-11 22 2041 22 6292
    intracellular organelle part 1.9119E-10 22 2282 22 6292
    organelle part 1.9119E-10 22 2282 22 6292
    preribosome, large subunit precursor 3.0753E-6 22 9 3 6292
    nuclear outer membrane 9.3062E-6 22 86 5 6292
    Noc2p-Noc3p complex 1.1672E-5 22 2 2 6292
    membrane-bounded organelle 1.2531E-5 22 3771 22 6292
    intracellular membrane-bounded organelle 1.2531E-5 22 3771 22 6292
    nuclear membrane 1.6796E-5 22 97 5 6292
    nuclear envelope 4.5341E-5 22 199 6 6292
    intracellular organelle 6.7452E-5 22 4070 22 6292
    organelle 6.7819E-5 22 4071 22 6292
    Noc complex 1.1598E-4 22 5 2 6292
    preribosome 2.07E-4 22 34 3 6292
    outer membrane 3.0497E-4 22 178 5 6292
    organelle outer membrane 3.0497E-4 22 178 5 6292
    nuclear membrane-endoplasmic reticulum network 1.0274E-3 22 232 5 6292
    endomembrane system 1.9297E-3 22 398 6 6292
    intracellular part 4.7906E-3 22 4938 22 6292
    intracellular 5.6476E-3 22 4975 22 6292
    envelope 6.3667E-3 22 505 6 6292
    organelle envelope 6.3667E-3 22 505 6 6292
    Noc1p-Noc2p complex 6.9813E-3 22 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.0142E-28 22 346 22 6292
    ribonucleoprotein complex biogenesis 5.9191E-28 22 374 22 6292
    ribosomal large subunit biogenesis 1.0649E-23 22 65 14 6292
    cellular component biogenesis 6.4039E-22 22 694 22 6292
    ribosome assembly 2.9186E-13 22 64 9 6292
    organelle assembly 5.9497E-13 22 69 9 6292
    ribonucleoprotein complex assembly 8.7344E-12 22 92 9 6292
    ribosomal large subunit assembly 4.6249E-11 22 41 7 6292
    ribosomal subunit assembly 4.0537E-10 22 55 7 6292
    cellular macromolecular complex assembly 4.187E-9 22 182 9 6292
    cellular macromolecular complex subunit organization 9.1872E-8 22 259 9 6292
    rRNA processing 1.6187E-7 22 128 7 6292
    macromolecular complex assembly 1.8547E-7 22 281 9 6292
    rRNA metabolic process 2.5841E-7 22 137 7 6292
    macromolecular complex subunit organization 1.4191E-6 22 357 9 6292
    establishment of ribosome localization 1.5937E-6 22 26 4 6292
    ribosome localization 1.5937E-6 22 26 4 6292
    ribosomal subunit export from nucleus 1.5937E-6 22 26 4 6292
    cellular component assembly 2.6708E-6 22 385 9 6292
    ncRNA processing 5.4328E-6 22 215 7 6292
    ncRNA metabolic process 1.7598E-5 22 257 7 6292
    establishment of organelle localization 3.4016E-5 22 55 4 6292
    organelle localization 1.8849E-4 22 85 4 6292
    RNA processing 2.1411E-4 22 380 7 6292
    nuclear export 3.949E-4 22 103 4 6292
    cellular process 4.2871E-4 22 4426 22 6292
    nuclear transport 9.5345E-4 22 130 4 6292
    nucleocytoplasmic transport 9.5345E-4 22 130 4 6292
    processing of 27S pre-rRNA 1.3596E-3 22 16 2 6292
    organelle organization 9.7965E-3 22 1127 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 2.1727E-6 22 28 4 6292
    RNA-dependent ATPase activity 2.5146E-6 22 29 4 6292
    RNA helicase activity 1.1502E-5 22 42 4 6292
    ATP-dependent helicase activity 1.9721E-5 22 48 4 6292
    purine NTP-dependent helicase activity 1.9721E-5 22 48 4 6292
    rRNA binding 2.0179E-5 22 16 3 6292
    rRNA primary transcript binding 1.1598E-4 22 5 2 6292
    helicase activity 1.7186E-4 22 83 4 6292
    ATPase activity 6.6788E-4 22 211 5 6292
    nucleoside-triphosphatase activity 7.1362E-4 22 329 6 6292
    hydrolase activity, acting on acid anhydrides 1.0348E-3 22 353 6 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.0348E-3 22 353 6 6292
    pyrophosphatase activity 1.0348E-3 22 353 6 6292
    ATPase activity, coupled 1.5844E-3 22 149 4 6292
    5S rRNA binding 6.9813E-3 22 2 1 6292
    RNA binding 7.5822E-3 22 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle