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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 17 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • SPB1
  • nucleus
  • nucleolus
  • rRNA methylation
  • processing of 27S pre-rRNA
  • rRNA (uridine-2'-O-)-methyltransferase activity
  • rRNA (guanine) methyltransferase activity
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 4.5214E-26 17 211 17 6292
    nuclear lumen 2.8292E-20 17 453 17 6292
    organelle lumen 1.8706E-17 17 660 17 6292
    intracellular organelle lumen 1.8706E-17 17 660 17 6292
    membrane-enclosed lumen 5.1476E-17 17 700 17 6292
    non-membrane-bounded organelle 1.1454E-14 17 959 17 6292
    intracellular non-membrane-bounded organelle 1.1454E-14 17 959 17 6292
    nuclear part 1.2588E-13 17 1103 17 6292
    nucleus 4.6591E-9 17 2041 17 6292
    organelle part 3.129E-8 17 2282 17 6292
    intracellular organelle part 3.129E-8 17 2282 17 6292
    nuclear outer membrane 6.761E-5 17 86 4 6292
    nuclear membrane 1.0831E-4 17 97 4 6292
    nuclear envelope 1.3655E-4 17 199 5 6292
    membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    intracellular membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    preribosome, large subunit precursor 2.4464E-4 17 9 2 6292
    intracellular organelle 6.0057E-4 17 4070 17 6292
    organelle 6.0308E-4 17 4071 17 6292
    outer membrane 1.1042E-3 17 178 4 6292
    organelle outer membrane 1.1042E-3 17 178 4 6292
    nuclear membrane-endoplasmic reticulum network 2.934E-3 17 232 4 6292
    endomembrane system 3.2383E-3 17 398 5 6292
    preribosome 3.6639E-3 17 34 2 6292
    Noc1p-Noc2p complex 5.3968E-3 17 2 1 6292
    envelope 8.9705E-3 17 505 5 6292
    organelle envelope 8.9705E-3 17 505 5 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 2.6351E-22 17 346 17 6292
    ribonucleoprotein complex biogenesis 1.0198E-21 17 374 17 6292
    ribosomal large subunit biogenesis 3.0134E-21 17 65 12 6292
    cellular component biogenesis 4.4392E-17 17 694 17 6292
    rRNA processing 2.0093E-8 17 128 7 6292
    rRNA metabolic process 3.228E-8 17 137 7 6292
    ribosome assembly 5.2335E-7 17 64 5 6292
    ncRNA processing 7.1713E-7 17 215 7 6292
    organelle assembly 7.6527E-7 17 69 5 6292
    ncRNA metabolic process 2.3934E-6 17 257 7 6292
    ribonucleoprotein complex assembly 3.2275E-6 17 92 5 6292
    ribosomal large subunit assembly 3.4746E-6 17 41 4 6292
    processing of 27S pre-rRNA 8.9795E-6 17 16 3 6292
    ribosomal subunit assembly 1.1433E-5 17 55 4 6292
    RNA processing 3.1795E-5 17 380 7 6292
    cellular macromolecular complex assembly 8.9383E-5 17 182 5 6292
    cellular macromolecular complex subunit organization 4.6809E-4 17 259 5 6292
    obsolete_biological_process 5.098E-4 17 60 3 6292
    macromolecular complex assembly 6.8097E-4 17 281 5 6292
    macromolecular complex subunit organization 2.0056E-3 17 357 5 6292
    establishment of ribosome localization 2.1497E-3 17 26 2 6292
    ribosome localization 2.1497E-3 17 26 2 6292
    ribosomal subunit export from nucleus 2.1497E-3 17 26 2 6292
    cellular process 2.5051E-3 17 4426 17 6292
    cellular component assembly 2.7998E-3 17 385 5 6292
    actomyosin structure organization 8.0849E-3 17 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 8.0849E-3 17 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 8.0849E-3 17 3 1 6292
    rRNA methylation 8.0849E-3 17 3 1 6292
    RNA metabolic process 8.6957E-3 17 954 7 6292
    establishment of organelle localization 9.3809E-3 17 55 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 5.1487E-5 17 28 3 6292
    RNA-dependent ATPase activity 5.7332E-5 17 29 3 6292
    RNA helicase activity 1.7625E-4 17 42 3 6292
    ATP-dependent helicase activity 2.6289E-4 17 48 3 6292
    purine NTP-dependent helicase activity 2.6289E-4 17 48 3 6292
    helicase activity 1.3172E-3 17 83 3 6292
    RNA methyltransferase activity 2.1497E-3 17 26 2 6292
    ribosomal large subunit binding 2.7018E-3 17 1 1 6292
    ATPase activity, coupled 6.9354E-3 17 149 3 6292
    rRNA (guanine) methyltransferase activity 8.0849E-3 17 3 1 6292
    rRNA (uridine) methyltransferase activity 8.0849E-3 17 3 1 6292
    rRNA (uridine-2'-O-)-methyltransferase activity 8.0849E-3 17 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle