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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • RIX7
  • nucleus
  • nucleolus
  • ribosomal large subunit export from nucleus
  • ATPase activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • SPB1
  • nucleus
  • nucleolus
  • rRNA methylation
  • processing of 27S pre-rRNA
  • rRNA (uridine-2'-O-)-methyltransferase activity
  • rRNA (guanine) methyltransferase activity
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.3978E-27 18 211 18 6292
    nuclear lumen 1.9658E-21 18 453 18 6292
    organelle lumen 1.9168E-18 18 660 18 6292
    intracellular organelle lumen 1.9168E-18 18 660 18 6292
    membrane-enclosed lumen 5.6029E-18 18 700 18 6292
    non-membrane-bounded organelle 1.7195E-15 18 959 18 6292
    intracellular non-membrane-bounded organelle 1.7195E-15 18 959 18 6292
    nuclear part 2.1786E-14 18 1103 18 6292
    nucleus 1.5028E-9 18 2041 18 6292
    organelle part 1.1294E-8 18 2282 18 6292
    intracellular organelle part 1.1294E-8 18 2282 18 6292
    membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    preribosome, large subunit precursor 2.7502E-4 18 9 2 6292
    intracellular organelle 3.879E-4 18 4070 18 6292
    organelle 3.8963E-4 18 4071 18 6292
    nuclear outer membrane 1.7345E-3 18 86 3 6292
    nuclear envelope 2.0962E-3 18 199 4 6292
    nuclear membrane 2.4501E-3 18 97 3 6292
    preribosome 4.1079E-3 18 34 2 6292
    Noc1p-Noc2p complex 5.7138E-3 18 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 1.3816E-23 18 346 18 6292
    ribonucleoprotein complex biogenesis 5.8017E-23 18 374 18 6292
    ribosomal large subunit biogenesis 8.9699E-21 18 65 12 6292
    cellular component biogenesis 4.7894E-18 18 694 18 6292
    ribosome assembly 1.4718E-8 18 64 6 6292
    organelle assembly 2.334E-8 18 69 6 6292
    rRNA processing 3.2326E-8 18 128 7 6292
    rRNA metabolic process 5.1867E-8 18 137 7 6292
    ribosomal large subunit assembly 7.3539E-8 18 41 5 6292
    ribonucleoprotein complex assembly 1.3366E-7 18 92 6 6292
    ribosomal subunit assembly 3.332E-7 18 55 5 6292
    ncRNA processing 1.1396E-6 18 215 7 6292
    ncRNA metabolic process 3.7807E-6 18 257 7 6292
    cellular macromolecular complex assembly 7.4975E-6 18 182 6 6292
    RNA processing 4.9348E-5 18 380 7 6292
    cellular macromolecular complex subunit organization 5.612E-5 18 259 6 6292
    macromolecular complex assembly 8.8608E-5 18 281 6 6292
    macromolecular complex subunit organization 3.3144E-4 18 357 6 6292
    cellular component assembly 4.9868E-4 18 385 6 6292
    processing of 27S pre-rRNA 9.059E-4 18 16 2 6292
    cellular process 1.7601E-3 18 4426 18 6292
    establishment of ribosome localization 2.4123E-3 18 26 2 6292
    ribosome localization 2.4123E-3 18 26 2 6292
    ribosomal subunit export from nucleus 2.4123E-3 18 26 2 6292
    actomyosin structure organization 8.5592E-3 18 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 8.5592E-3 18 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 8.5592E-3 18 3 1 6292
    rRNA methylation 8.5592E-3 18 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 6.1601E-5 18 28 3 6292
    RNA-dependent ATPase activity 6.8585E-5 18 29 3 6292
    RNA helicase activity 2.1052E-4 18 42 3 6292
    ATP-dependent helicase activity 3.1378E-4 18 48 3 6292
    purine NTP-dependent helicase activity 3.1378E-4 18 48 3 6292
    rRNA binding 9.059E-4 18 16 2 6292
    helicase activity 1.5656E-3 18 83 3 6292
    nucleoside-triphosphatase activity 1.8464E-3 18 329 5 6292
    RNA methyltransferase activity 2.4123E-3 18 26 2 6292
    hydrolase activity, acting on acid anhydrides 2.5214E-3 18 353 5 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 2.5214E-3 18 353 5 6292
    pyrophosphatase activity 2.5214E-3 18 353 5 6292
    ATPase activity 2.5973E-3 18 211 4 6292
    5S rRNA binding 5.7138E-3 18 2 1 6292
    ATPase activity, coupled 8.1798E-3 18 149 3 6292
    rRNA (guanine) methyltransferase activity 8.5592E-3 18 3 1 6292
    rRNA (uridine) methyltransferase activity 8.5592E-3 18 3 1 6292
    rRNA (uridine-2'-O-)-methyltransferase activity 8.5592E-3 18 3 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle