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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 12 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • RPL15A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL20B
  • ribosome biogenesis
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL4B
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPS11A, RPS11B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS3
  • preribosome, small subunit precursor
  • response to DNA damage stimulus
  • translation
  • structural constituent of ribosome
  • RPS6A, RPS6B
  • small-subunit processome
  • nucleus
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • nucleolus
  • 90S preribosome
  • intracellular
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • rRNA processing
  • translation
  • structural constituent of ribosome
  • RPS7A
  • small nucleolar ribonucleoprotein complex
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    preribosome 1.4126E-11 12 34 6 6292
    90S preribosome 5.9069E-11 12 17 5 6292
    cytosolic ribosome 1.652E-10 12 101 7 6292
    cytosolic part 6.3389E-10 12 122 7 6292
    cytosolic small ribosomal subunit 4.6987E-9 12 38 5 6292
    ribosomal subunit 1.1004E-8 12 183 7 6292
    ribonucleoprotein complex 2.6676E-8 12 514 9 6292
    small ribosomal subunit 1.3609E-7 12 73 5 6292
    cytosol 2.3132E-7 12 284 7 6292
    ribosome 2.6703E-7 12 290 7 6292
    macromolecular complex 5.2917E-4 12 1635 9 6292
    non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    intracellular non-membrane-bounded organelle 7.3226E-4 12 959 7 6292
    cytosolic large ribosomal subunit 5.5506E-3 12 60 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 1.7552E-15 12 376 12 6292
    cellular protein metabolic process 5.8125E-10 12 1074 12 6292
    protein metabolic process 1.1437E-9 12 1136 12 6292
    cellular macromolecule biosynthetic process 1.9421E-9 12 1187 12 6292
    macromolecule biosynthetic process 1.9819E-9 12 1189 12 6292
    gene expression 4.9591E-9 12 1283 12 6292
    cellular biosynthetic process 5.5155E-8 12 1567 12 6292
    biosynthetic process 7.1963E-8 12 1602 12 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.5001E-6 12 13 3 6292
    cellular macromolecule metabolic process 5.1661E-6 12 2285 12 6292
    macromolecule metabolic process 7.2022E-6 12 2349 12 6292
    primary metabolic process 8.9282E-5 12 2896 12 6292
    regulation of translation 1.4638E-4 12 57 3 6292
    cellular metabolic process 1.5563E-4 12 3033 12 6292
    maturation of SSU-rRNA 1.6228E-4 12 59 3 6292
    posttranscriptional regulation of gene expression 1.7927E-4 12 61 3 6292
    regulation of cellular protein metabolic process 2.4776E-4 12 68 3 6292
    metabolic process 2.5194E-4 12 3157 12 6292
    regulation of protein metabolic process 3.184E-4 12 74 3 6292
    rRNA processing 1.5818E-3 12 128 3 6292
    rRNA metabolic process 1.9237E-3 12 137 3 6292
    ribosome biogenesis 3.1264E-3 12 346 4 6292
    ribonucleoprotein complex biogenesis 4.1497E-3 12 374 4 6292
    ncRNA processing 6.8876E-3 12 215 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 5.7344E-16 12 212 11 6292
    structural molecule activity 1.0864E-13 12 339 11 6292
    rRNA binding 3.9428E-4 12 16 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle