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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • LSM1
  • mRNA cap binding complex
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • RNA binding
  • RNA cap binding
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PAT1
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • chromosome segregation
  • regulation of translational initiation
  • molecular_function
  • PRP24
  • U6 snRNP
  • spliceosome assembly
  • assembly of spliceosomal tri-snRNP
  • nucleic acid binding
  • nucleotide binding
  • U6 snRNA binding
  • RNA binding
  • snRNA binding
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 2.8288E-15 10 63 8 6292
    U4/U6 x U5 tri-snRNP complex 5.1772E-15 10 32 7 6292
    ribonucleoprotein complex 1.2207E-11 10 514 10 6292
    U6 snRNP 1.0565E-9 10 11 4 6292
    macromolecular complex 1.3754E-6 10 1635 10 6292
    nuclear part 2.8079E-5 10 1103 8 6292
    small nucleolar ribonucleoprotein complex 1.6279E-4 10 72 3 6292
    U5 snRNP 2.0481E-4 10 14 2 6292
    cytoplasmic mRNA processing body 2.3612E-4 10 15 2 6292
    nucleus 2.7794E-3 10 2041 8 6292
    nucleolus 3.747E-3 10 211 3 6292
    mRNA cap binding complex 4.7611E-3 10 3 1 6292
    organelle part 6.1675E-3 10 2282 8 6292
    intracellular organelle part 6.1675E-3 10 2282 8 6292
    RNA cap binding complex 9.5019E-3 10 6 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA metabolic process 1.6065E-15 10 213 10 6292
    nuclear mRNA splicing, via spliceosome 1.2377E-13 10 99 8 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.3449E-13 10 100 8 6292
    RNA splicing, via transesterification reactions 2.351E-13 10 107 8 6292
    RNA splicing 1.3187E-12 10 132 8 6292
    mRNA processing 5.155E-12 10 156 8 6292
    RNA metabolic process 6.1681E-9 10 954 10 6292
    RNA processing 6.6673E-9 10 380 8 6292
    mRNA catabolic process 3.3078E-8 10 69 5 6292
    RNA catabolic process 7.0238E-8 10 80 5 6292
    nucleic acid metabolic process 3.2281E-7 10 1415 10 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.9255E-7 10 1566 10 6292
    cellular nitrogen compound metabolic process 3.0471E-6 10 1770 10 6292
    nitrogen compound metabolic process 3.4296E-6 10 1791 10 6292
    gene expression 4.872E-6 10 1283 9 6292
    cellular macromolecule catabolic process 2.7032E-5 10 265 5 6292
    cellular macromolecule metabolic process 3.9402E-5 10 2285 10 6292
    macromolecule catabolic process 4.4709E-5 10 294 5 6292
    macromolecule metabolic process 5.1966E-5 10 2349 10 6292
    deadenylation-dependent decapping of nuclear-transcribed mRNA 1.241E-4 10 11 2 6292
    cellular catabolic process 2.3277E-4 10 415 5 6292
    primary metabolic process 4.2311E-4 10 2896 10 6292
    catabolic process 5.3853E-4 10 496 5 6292
    cellular metabolic process 6.7219E-4 10 3033 10 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 7.8132E-4 10 27 2 6292
    metabolic process 1.0041E-3 10 3157 10 6292
    nuclear-transcribed mRNA catabolic process 1.5503E-3 10 38 2 6292
    spliceosomal snRNP assembly 3.1764E-3 10 2 1 6292
    assembly of spliceosomal tri-snRNP 3.1764E-3 10 2 1 6292
    generation of catalytic spliceosome for first transesterification step 4.7611E-3 10 3 1 6292
    ribonucleoprotein complex assembly 8.8178E-3 10 92 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 6.5031E-6 10 367 6 6292
    snRNA binding 2.2679E-5 10 5 2 6292
    nucleic acid binding 1.9872E-4 10 666 6 6292
    binding 1.0216E-3 10 1294 7 6292
    U6 snRNA binding 1.5893E-3 10 1 1 6292
    RNA cap binding 3.1764E-3 10 2 1 6292
    U5 snRNA binding 3.1764E-3 10 2 1 6292
    nucleotide binding 3.7066E-3 10 59 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle