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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • KEM1
  • cytoplasm
  • cytoplasmic mRNA processing body
  • nuclear outer membrane
  • filamentous growth
  • response to exogenous dsRNA
  • telomere maintenance
  • traversing start control point of mitotic cell cycle
  • karyogamy involved in conjugation with cellular fusion
  • mRNA catabolic process
  • 5'-3' exoribonuclease activity
  • deoxyribonuclease activity
  • recombinase activity
  • LSM1
  • mRNA cap binding complex
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • RNA binding
  • RNA cap binding
  • LSM2
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM4
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM6
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • LSM7
  • U4/U6 x U5 tri-snRNP complex
  • nucleolus
  • U6 snRNP
  • small nucleolar ribonucleoprotein complex
  • telomere maintenance
  • mRNA catabolic process
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PAT1
  • cytoplasmic mRNA processing body
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
  • chromosome segregation
  • regulation of translational initiation
  • molecular_function
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U4/U6 x U5 tri-snRNP complex 6.8681E-22 13 32 10 6292
    small nuclear ribonucleoprotein complex 1.3424E-18 13 63 10 6292
    ribonucleoprotein complex 6.2692E-15 13 514 13 6292
    U6 snRNP 3.5876E-9 13 11 4 6292
    macromolecular complex 2.3774E-8 13 1635 13 6292
    nuclear part 2.5417E-7 13 1103 11 6292
    U5 snRNP 2.476E-6 13 14 3 6292
    cytoplasmic mRNA processing body 3.0914E-6 13 15 3 6292
    small nucleolar ribonucleoprotein complex 1.0427E-5 13 72 4 6292
    nucleus 1.5889E-4 13 2041 11 6292
    organelle part 4.9114E-4 13 2282 11 6292
    intracellular organelle part 4.9114E-4 13 2282 11 6292
    nucleolus 6.9245E-4 13 211 4 6292
    mRNA cap binding complex 6.1865E-3 13 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    mRNA metabolic process 5.3435E-20 13 213 13 6292
    nuclear mRNA splicing, via spliceosome 1.6107E-16 13 99 10 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.7888E-16 13 100 10 6292
    RNA splicing, via transesterification reactions 3.6199E-16 13 107 10 6292
    RNA splicing 3.1796E-15 13 132 10 6292
    mRNA processing 1.7665E-14 13 156 10 6292
    RNA metabolic process 2.0874E-11 13 954 13 6292
    mRNA catabolic process 2.2765E-11 13 69 7 6292
    RNA catabolic process 6.6411E-11 13 80 7 6292
    RNA processing 1.3992E-10 13 380 10 6292
    nucleic acid metabolic process 3.6054E-9 13 1415 13 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.3544E-8 13 1566 13 6292
    cellular nitrogen compound metabolic process 6.6927E-8 13 1770 13 6292
    nitrogen compound metabolic process 7.8058E-8 13 1791 13 6292
    cellular macromolecule catabolic process 3.001E-7 13 265 7 6292
    macromolecule catabolic process 6.1026E-7 13 294 7 6292
    gene expression 1.2671E-6 13 1283 11 6292
    cellular macromolecule metabolic process 1.8698E-6 13 2285 13 6292
    macromolecule metabolic process 2.6802E-6 13 2349 13 6292
    cellular catabolic process 6.2609E-6 13 415 7 6292
    catabolic process 2.047E-5 13 496 7 6292
    primary metabolic process 4.1002E-5 13 2896 13 6292
    cellular metabolic process 7.4867E-5 13 3033 13 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    spliceosomal conformational changes to generate catalytic conformation 1.4073E-4 13 9 2 6292
    deadenylation-dependent decapping of nuclear-transcribed mRNA 2.145E-4 13 11 2 6292
    ribonucleoprotein complex assembly 7.7815E-4 13 92 3 6292
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1.3436E-3 13 27 2 6292
    regulation of hormone levels 2.0661E-3 13 1 1 6292
    hormone metabolic process 2.0661E-3 13 1 1 6292
    hormone biosynthetic process 2.0661E-3 13 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.0661E-3 13 1 1 6292
    auxin biosynthetic process 2.0661E-3 13 1 1 6292
    auxin metabolic process 2.0661E-3 13 1 1 6292
    nuclear-transcribed mRNA catabolic process 2.6567E-3 13 38 2 6292
    nuclear mRNA 3'-splice site recognition 4.1283E-3 13 2 1 6292
    cellular macromolecular complex assembly 5.4966E-3 13 182 3 6292
    generation of catalytic spliceosome for first transesterification step 6.1865E-3 13 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 1.2363E-7 13 367 8 6292
    U5 snRNA binding 3.9411E-6 13 2 2 6292
    nucleic acid binding 1.1996E-5 13 666 8 6292
    snRNA binding 3.9273E-5 13 5 2 6292
    binding 1.4925E-3 13 1294 8 6292
    RNA cap binding 4.1283E-3 13 2 1 6292
    5'-3' exoribonuclease activity 4.1283E-3 13 2 1 6292
    recombinase activity 8.2408E-3 13 4 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle