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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 16 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CUS1
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • protein binding
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP11
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • PRP21
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • PRP9
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • STO1
  • commitment complex
  • nuclear cap binding complex
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 2.69E-30 16 63 15 6292
    U5 snRNP 6.3289E-19 16 14 8 6292
    ribonucleoprotein complex 3.167E-18 16 514 16 6292
    U2 snRNP 2.5237E-16 16 13 7 6292
    U4/U6 x U5 tri-snRNP complex 2.1719E-15 16 32 8 6292
    nuclear part 7.2679E-13 16 1103 16 6292
    macromolecular complex 4.0924E-10 16 1635 16 6292
    nucleus 1.444E-8 16 2041 16 6292
    U1 snRNP 6.5086E-8 16 17 4 6292
    organelle part 8.6662E-8 16 2282 16 6292
    intracellular organelle part 8.6662E-8 16 2282 16 6292
    commitment complex 2.9278E-6 16 12 3 6292
    U2-type spliceosomal complex 2.9278E-6 16 12 3 6292
    spliceosomal complex 1.7941E-4 16 45 3 6292
    membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    nuclear cap binding complex 7.6106E-3 16 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 3.9955E-30 16 99 16 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 4.7565E-30 16 100 16 6292
    RNA splicing, via transesterification reactions 1.5324E-29 16 107 16 6292
    RNA splicing 5.5669E-28 16 132 16 6292
    mRNA processing 9.3744E-27 16 156 16 6292
    mRNA metabolic process 1.7018E-24 16 213 16 6292
    RNA processing 2.3182E-20 16 380 16 6292
    RNA metabolic process 7.0068E-14 16 954 16 6292
    gene expression 8.2892E-12 16 1283 16 6292
    nucleic acid metabolic process 4.0069E-11 16 1415 16 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0462E-10 16 1566 16 6292
    spliceosome assembly 4.4756E-10 16 18 5 6292
    ribonucleoprotein complex assembly 1.1663E-9 16 92 7 6292
    cellular nitrogen compound metabolic process 1.4646E-9 16 1770 16 6292
    nitrogen compound metabolic process 1.7702E-9 16 1791 16 6292
    cellular macromolecule metabolic process 8.851E-8 16 2285 16 6292
    macromolecule metabolic process 1.379E-7 16 2349 16 6292
    cellular macromolecular complex assembly 1.3862E-7 16 182 7 6292
    cellular macromolecular complex subunit organization 1.5367E-6 16 259 7 6292
    macromolecular complex assembly 2.66E-6 16 281 7 6292
    primary metabolic process 3.9666E-6 16 2896 16 6292
    cellular metabolic process 8.3256E-6 16 3033 16 6292
    macromolecular complex subunit organization 1.3081E-5 16 357 7 6292
    metabolic process 1.5832E-5 16 3157 16 6292
    ribonucleoprotein complex biogenesis 1.7765E-5 16 374 7 6292
    cellular component assembly 2.1484E-5 16 385 7 6292
    spliceosomal conformational changes to generate catalytic conformation 2.1602E-4 16 9 2 6292
    cellular component biogenesis 9.0035E-4 16 694 7 6292
    regulation of hormone levels 2.5429E-3 16 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.5429E-3 16 1 1 6292
    auxin biosynthetic process 2.5429E-3 16 1 1 6292
    auxin metabolic process 2.5429E-3 16 1 1 6292
    hormone metabolic process 2.5429E-3 16 1 1 6292
    hormone biosynthetic process 2.5429E-3 16 1 1 6292
    cellular process 3.565E-3 16 4426 16 6292
    nuclear mRNA 3'-splice site recognition 5.0798E-3 16 2 1 6292
    generation of catalytic spliceosome for first transesterification step 7.6106E-3 16 3 1 6292
    cellular component organization 7.7019E-3 16 1582 9 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 4.4864E-16 16 367 14 6292
    nucleic acid binding 1.9177E-12 16 666 14 6292
    binding 1.8014E-8 16 1294 14 6292
    snRNA binding 1.3453E-7 16 5 3 6292
    mRNA binding 1.393E-6 16 35 4 6292
    U5 snRNA binding 6.0632E-6 16 2 2 6292
    U2 snRNA binding 2.5429E-3 16 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle