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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CUS1
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • protein binding
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP11
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • PRP21
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • PRP9
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • STO1
  • commitment complex
  • nuclear cap binding complex
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 2.8186E-25 15 63 13 6292
    ribonucleoprotein complex 3.9839E-17 15 514 15 6292
    U2 snRNP 1.4208E-16 15 13 7 6292
    U5 snRNP 1.7311E-13 15 14 6 6292
    nuclear part 4.193E-12 15 1103 15 6292
    U4/U6 x U5 tri-snRNP complex 5.1095E-11 15 32 6 6292
    macromolecular complex 1.5857E-9 15 1635 15 6292
    nucleus 4.4738E-8 15 2041 15 6292
    organelle part 2.3996E-7 15 2282 15 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    spliceosomal complex 1.465E-4 15 45 3 6292
    commitment complex 3.4536E-4 15 12 2 6292
    U2-type spliceosomal complex 3.4536E-4 15 12 2 6292
    membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    intracellular membrane-bounded organelle 4.5726E-4 15 3771 15 6292
    U1 snRNP 7.0676E-4 15 17 2 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292
    nuclear cap binding complex 7.136E-3 15 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 2.9857E-28 15 99 15 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 3.5126E-28 15 100 15 6292
    RNA splicing, via transesterification reactions 1.0455E-27 15 107 15 6292
    RNA splicing 2.9866E-26 15 132 15 6292
    mRNA processing 4.1733E-25 15 156 15 6292
    mRNA metabolic process 5.3951E-23 15 213 15 6292
    RNA processing 3.9867E-19 15 380 15 6292
    RNA metabolic process 4.6839E-13 15 954 15 6292
    gene expression 4.1034E-11 15 1283 15 6292
    nucleic acid metabolic process 1.7965E-10 15 1415 15 6292
    spliceosome assembly 3.0823E-10 15 18 5 6292
    ribonucleoprotein complex assembly 6.6388E-10 15 92 7 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.2811E-10 15 1566 15 6292
    cellular nitrogen compound metabolic process 5.2383E-9 15 1770 15 6292
    nitrogen compound metabolic process 6.2564E-9 15 1791 15 6292
    cellular macromolecular complex assembly 7.9917E-8 15 182 7 6292
    cellular macromolecule metabolic process 2.4475E-7 15 2285 15 6292
    macromolecule metabolic process 3.7086E-7 15 2349 15 6292
    cellular macromolecular complex subunit organization 8.9573E-7 15 259 7 6292
    macromolecular complex assembly 1.5553E-6 15 281 7 6292
    macromolecular complex subunit organization 7.7325E-6 15 357 7 6292
    primary metabolic process 8.6423E-6 15 2896 15 6292
    ribonucleoprotein complex biogenesis 1.0527E-5 15 374 7 6292
    cellular component assembly 1.2752E-5 15 385 7 6292
    cellular metabolic process 1.7316E-5 15 3033 15 6292
    metabolic process 3.1628E-5 15 3157 15 6292
    spliceosomal conformational changes to generate catalytic conformation 1.8916E-4 15 9 2 6292
    cellular component biogenesis 5.5922E-4 15 694 7 6292
    regulation of hormone levels 2.384E-3 15 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.384E-3 15 1 1 6292
    auxin biosynthetic process 2.384E-3 15 1 1 6292
    auxin metabolic process 2.384E-3 15 1 1 6292
    hormone metabolic process 2.384E-3 15 1 1 6292
    hormone biosynthetic process 2.384E-3 15 1 1 6292
    cellular component organization 4.3261E-3 15 1582 9 6292
    nuclear mRNA 3'-splice site recognition 4.7627E-3 15 2 1 6292
    cellular process 5.0732E-3 15 4426 15 6292
    generation of catalytic spliceosome for first transesterification step 7.136E-3 15 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 5.0624E-13 15 367 12 6292
    nucleic acid binding 6.0799E-10 15 666 12 6292
    snRNA binding 1.0934E-7 15 5 3 6292
    binding 1.338E-6 15 1294 12 6292
    U5 snRNA binding 5.3053E-6 15 2 2 6292
    mRNA binding 6.8549E-5 15 35 3 6292
    U2 snRNA binding 2.384E-3 15 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle