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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 14 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CEF1
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • DNA binding
  • first spliceosomal transesterification activity
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC22
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    spliceosomal complex 1.0341E-14 14 45 8 6292
    ribonucleoprotein complex 8.1265E-14 14 514 13 6292
    nuclear part 1.6352E-9 14 1103 13 6292
    small nuclear ribonucleoprotein complex 1.6E-7 14 63 5 6292
    macromolecular complex 2.5299E-7 14 1635 13 6292
    organelle part 6.6422E-7 14 2282 14 6292
    intracellular organelle part 6.6422E-7 14 2282 14 6292
    U5 snRNP 3.1472E-6 14 14 3 6292
    nucleus 4.2048E-6 14 2041 13 6292
    U4/U6 x U5 tri-snRNP complex 4.1883E-5 14 32 3 6292
    U2 snRNP 3.5365E-4 14 13 2 6292
    intracellular organelle 2.2276E-3 14 4070 14 6292
    organelle 2.2353E-3 14 4071 14 6292
    membrane-bounded organelle 7.9402E-3 14 3771 13 6292
    intracellular membrane-bounded organelle 7.9402E-3 14 3771 13 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 2.2254E-23 14 99 13 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 2.5575E-23 14 100 13 6292
    RNA splicing, via transesterification reactions 6.5085E-23 14 107 13 6292
    RNA splicing 1.1531E-21 14 132 13 6292
    mRNA processing 1.1102E-20 14 156 13 6292
    mRNA metabolic process 7.2596E-19 14 213 13 6292
    RNA processing 1.5491E-15 14 380 13 6292
    RNA metabolic process 2.5156E-10 14 954 13 6292
    gene expression 1.1412E-8 14 1283 13 6292
    ribonucleoprotein complex assembly 2.2665E-8 14 92 6 6292
    nucleic acid metabolic process 4.0011E-8 14 1415 13 6292
    spliceosome assembly 4.6119E-8 14 18 4 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.4606E-7 14 1566 13 6292
    cellular nitrogen compound metabolic process 6.9352E-7 14 1770 13 6292
    nitrogen compound metabolic process 8.0547E-7 14 1791 13 6292
    cellular macromolecular complex assembly 1.3361E-6 14 182 6 6292
    cellular macromolecular complex subunit organization 1.0438E-5 14 259 6 6292
    macromolecular complex assembly 1.6684E-5 14 281 6 6292
    cellular macromolecule metabolic process 1.7382E-5 14 2285 13 6292
    macromolecule metabolic process 2.456E-5 14 2349 13 6292
    macromolecular complex subunit organization 6.5117E-5 14 357 6 6292
    ribonucleoprotein complex biogenesis 8.4596E-5 14 374 6 6292
    cellular component assembly 9.9527E-5 14 385 6 6292
    spliceosomal conformational changes to generate catalytic conformation 1.6406E-4 14 9 2 6292
    primary metabolic process 3.2929E-4 14 2896 13 6292
    cellular metabolic process 5.8003E-4 14 3033 13 6292
    metabolic process 9.4511E-4 14 3157 13 6292
    regulation of hormone levels 2.225E-3 14 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.225E-3 14 1 1 6292
    auxin biosynthetic process 2.225E-3 14 1 1 6292
    auxin metabolic process 2.225E-3 14 1 1 6292
    hormone metabolic process 2.225E-3 14 1 1 6292
    hormone biosynthetic process 2.225E-3 14 1 1 6292
    cellular component biogenesis 2.4266E-3 14 694 6 6292
    nuclear mRNA 3'-splice site recognition 4.4455E-3 14 2 1 6292
    cis assembly of pre-catalytic spliceosome 4.4455E-3 14 2 1 6292
    nuclear mRNA cis splicing, via spliceosome 6.6614E-3 14 3 1 6292
    generation of catalytic spliceosome for first transesterification step 6.6614E-3 14 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snRNA binding 8.7489E-8 14 5 3 6292
    U5 snRNA binding 4.5979E-6 14 2 2 6292
    first spliceosomal transesterification activity 6.8619E-5 14 6 2 6292
    RNA binding 8.4824E-4 14 367 5 6292
    nucleic acid binding 1.9573E-3 14 666 6 6292
    U2 snRNA binding 2.225E-3 14 1 1 6292
    binding 2.858E-3 14 1294 8 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle