YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CLF1
  • chromatin
  • DNA replication
  • cell cycle
  • cis assembly of pre-catalytic spliceosome
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • CWC2
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • CWC23
  • spliceosomal complex
  • biological_process
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
  • PRP43
  • mitochondrion
  • spliceosomal complex
  • nuclear outer membrane
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • processing of 27S pre-rRNA
  • ATP-dependent RNA helicase activity
  • PRP46
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SNT309
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • protein binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SPP382
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • SYF1
  • spliceosomal complex
  • cell cycle
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribonucleoprotein complex 6.9455E-15 15 514 14 6292
    spliceosomal complex 2.2044E-14 15 45 8 6292
    nuclear part 3.0389E-10 15 1103 14 6292
    small nuclear ribonucleoprotein complex 3.6873E-9 15 63 6 6292
    macromolecular complex 6.9919E-8 15 1635 14 6292
    organelle part 2.3996E-7 15 2282 15 6292
    intracellular organelle part 2.3996E-7 15 2282 15 6292
    nucleus 1.4521E-6 15 2041 14 6292
    U2 snRNP 3.0914E-6 15 13 3 6292
    U5 snRNP 3.9288E-6 15 14 3 6292
    U4/U6 x U5 tri-snRNP complex 5.2172E-5 15 32 3 6292
    intracellular organelle 1.4392E-3 15 4070 15 6292
    organelle 1.4445E-3 15 4071 15 6292
    membrane-bounded organelle 5.0597E-3 15 3771 14 6292
    intracellular membrane-bounded organelle 5.0597E-3 15 3771 14 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 1.6478E-22 15 99 13 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1.8935E-22 15 100 13 6292
    RNA splicing, via transesterification reactions 4.8135E-22 15 107 13 6292
    RNA splicing 8.4962E-21 15 132 13 6292
    mRNA processing 8.1505E-20 15 156 13 6292
    mRNA metabolic process 5.2837E-18 15 213 13 6292
    RNA processing 9.6995E-17 15 380 14 6292
    RNA metabolic process 4.0366E-11 15 954 14 6292
    gene expression 2.4706E-9 15 1283 14 6292
    nucleic acid metabolic process 9.5604E-9 15 1415 14 6292
    ribonucleoprotein complex assembly 3.7332E-8 15 92 6 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.8653E-8 15 1566 14 6292
    spliceosome assembly 6.2778E-8 15 18 4 6292
    cellular nitrogen compound metabolic process 2.0758E-7 15 1770 14 6292
    nitrogen compound metabolic process 2.4396E-7 15 1791 14 6292
    cellular macromolecular complex assembly 2.1736E-6 15 182 6 6292
    cellular macromolecule metabolic process 6.7223E-6 15 2285 14 6292
    macromolecule metabolic process 9.7648E-6 15 2349 14 6292
    ribonucleoprotein complex biogenesis 1.0527E-5 15 374 7 6292
    cellular macromolecular complex subunit organization 1.68E-5 15 259 6 6292
    macromolecular complex assembly 2.677E-5 15 281 6 6292
    macromolecular complex subunit organization 1.0337E-4 15 357 6 6292
    cellular component assembly 1.5738E-4 15 385 6 6292
    primary metabolic process 1.614E-4 15 2896 14 6292
    spliceosomal conformational changes to generate catalytic conformation 1.8916E-4 15 9 2 6292
    cellular metabolic process 2.9771E-4 15 3033 14 6292
    metabolic process 5.0484E-4 15 3157 14 6292
    cellular component biogenesis 5.5922E-4 15 694 7 6292
    regulation of hormone levels 2.384E-3 15 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.384E-3 15 1 1 6292
    auxin biosynthetic process 2.384E-3 15 1 1 6292
    auxin metabolic process 2.384E-3 15 1 1 6292
    hormone metabolic process 2.384E-3 15 1 1 6292
    hormone biosynthetic process 2.384E-3 15 1 1 6292
    nuclear mRNA 3'-splice site recognition 4.7627E-3 15 2 1 6292
    cis assembly of pre-catalytic spliceosome 4.7627E-3 15 2 1 6292
    nuclear mRNA cis splicing, via spliceosome 7.136E-3 15 3 1 6292
    generation of catalytic spliceosome for first transesterification step 7.136E-3 15 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    snRNA binding 1.0934E-7 15 5 3 6292
    U5 snRNA binding 5.3053E-6 15 2 2 6292
    RNA binding 9.2886E-6 15 367 7 6292
    nucleic acid binding 4.331E-4 15 666 7 6292
    binding 9.5787E-4 15 1294 9 6292
    ATP-dependent RNA helicase activity 1.9348E-3 15 28 2 6292
    RNA-dependent ATPase activity 2.0753E-3 15 29 2 6292
    U2 snRNA binding 2.384E-3 15 1 1 6292
    RNA helicase activity 4.323E-3 15 42 2 6292
    ATP-dependent helicase activity 5.6171E-3 15 48 2 6292
    purine NTP-dependent helicase activity 5.6171E-3 15 48 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle