Combinatorial control required for the specificity of yeast MAPK signaling

Science. 1997 Feb 28;275(5304):1314-7. doi: 10.1126/science.275.5304.1314.

Abstract

In yeast, an overlapping set of mitogen-activated protein kinase (MAPK) signaling components controls mating, haploid invasion, and pseudohyphal development. Paradoxically, a single downstream transcription factor, Ste12, is necessary for the execution of these distinct programs. Developmental specificity was found to require a transcription factor of the TEA/ATTS family, Tec1, which cooperates with Ste12 during filamentous and invasive growth. Purified derivatives of Ste12 and Tec1 bind cooperatively to enhancer elements called filamentation and invasion response elements (FREs), which program transcription that is specifically responsive to the MAPK signaling components required for filamentous growth. An FRE in the TEC1 promoter functions in a positive feedback loop required for pseudohyphal development.

MeSH terms

  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Enhancer Elements, Genetic*
  • Fungal Proteins / metabolism*
  • Intracellular Signaling Peptides and Proteins
  • MAP Kinase Kinase Kinases / metabolism
  • Mitogen-Activated Protein Kinase Kinases
  • Mutation
  • Protein Kinases / metabolism
  • Protein Serine-Threonine Kinases / metabolism
  • Retroelements
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins*
  • Schizosaccharomyces pombe Proteins*
  • Signal Transduction
  • Transcription Factors*
  • Transcription, Genetic

Substances

  • DNA-Binding Proteins
  • Fungal Proteins
  • Intracellular Signaling Peptides and Proteins
  • Retroelements
  • STE12 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • TEC1 protein, S cerevisiae
  • Transcription Factors
  • ste11 protein, S pombe
  • Protein Kinases
  • Protein Serine-Threonine Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • MAP Kinase Kinase Kinases
  • STE20 protein, S cerevisiae
  • Ste11 protein, S cerevisiae
  • Mitogen-Activated Protein Kinase Kinases