Abstract
The NHA1 gene (2958 nt) encoding a putative Na(+)/H(+) antiporter (986 aa) in Saccharomyces cerevisiae was cloned by selection based on increased NaCl tolerance. The putative protein is highly similar to sodium/proton antiporters from Schizosaccharomyces pombe (gene sod2), and Zygosaccharomyces rouxii (gene Z-SOD2). Overexpression of the NHA1 gene results in higher and partially pH-dependent tolerance to sodium and lithium; its disruption leads to an increased sensitivity towards these ions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cation Transport Proteins*
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Cloning, Molecular
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DNA, Fungal
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Membrane Proteins / metabolism*
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Molecular Sequence Data
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Plasmids
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Saccharomyces cerevisiae / drug effects
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins*
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Sequence Homology, Amino Acid
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Sodium Chloride / pharmacology
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Sodium-Hydrogen Exchangers / genetics
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Sodium-Hydrogen Exchangers / metabolism*
Substances
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Cation Transport Proteins
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DNA, Fungal
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Membrane Proteins
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NHA1 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Sodium-Hydrogen Exchangers
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Sodium Chloride