Abstract
The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentrations (0.3 M) induction is mediated by the HOG-MAP kinase pathway, a system activated by non-specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG-mediated induction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine Triphosphatases / genetics*
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Calcineurin
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Calcium-Calmodulin-Dependent Protein Kinases / physiology
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Calmodulin-Binding Proteins / antagonists & inhibitors
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Calmodulin-Binding Proteins / physiology
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Cation Transport Proteins*
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Cell Cycle Proteins*
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Cyclic AMP-Dependent Protein Kinases / physiology
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Enzyme Inhibitors / pharmacology
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Fungal Proteins / physiology
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Gene Expression Regulation, Fungal / drug effects*
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Genes, Fungal / genetics
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Genes, Reporter
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Ion Transport
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Osmotic Pressure
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Phosphoprotein Phosphatases / antagonists & inhibitors
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Phosphoprotein Phosphatases / physiology
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Recombinant Fusion Proteins / biosynthesis
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / physiology*
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Saccharomyces cerevisiae Proteins*
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Signal Transduction / physiology*
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Sodium / metabolism
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Sodium Chloride / pharmacology*
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Sodium-Potassium-Exchanging ATPase
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Tacrolimus / pharmacology
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beta-Galactosidase / genetics
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beta-Galactosidase / metabolism
Substances
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Calmodulin-Binding Proteins
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Cation Transport Proteins
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Cell Cycle Proteins
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ENA1 protein, S cerevisiae
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Enzyme Inhibitors
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Fungal Proteins
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Recombinant Fusion Proteins
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SIS2 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Sodium Chloride
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Sodium
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Cyclic AMP-Dependent Protein Kinases
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Calcium-Calmodulin-Dependent Protein Kinases
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Calcineurin
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Phosphoprotein Phosphatases
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beta-Galactosidase
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Adenosine Triphosphatases
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Sodium-Potassium-Exchanging ATPase
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Tacrolimus