Integral membrane protein located in the apical complex of Plasmodium falciparum

M G Peterson; V M Marshall; J A Smythe; P E Crewther; A Lew; A Silva; R F Anders; D J Kemp

doi:10.1128/mcb.9.7.3151-3154.1989

Integral membrane protein located in the apical complex of Plasmodium falciparum

Mol Cell Biol. 1989 Jul;9(7):3151-4. doi: 10.1128/mcb.9.7.3151-3154.1989.

Authors

M G Peterson¹, V M Marshall, J A Smythe, P E Crewther, A Lew, A Silva, R F Anders, D J Kemp

Affiliation

¹ Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Victoria, Australia.

Abstract

We describe the cloning of a novel antigen of Plasmodium falciparum which contains a hydrophobic domain typical of an integral membrane protein. This antigen is designated apical membrane antigen 1 because it appears to be located in the apical complex. Apical membrane antigen 1 appears to be transported to the merozoite surface near the time of schizont rupture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Antigens, Protozoan / genetics*
Base Sequence
Cloning, Molecular
DNA / genetics*
Membrane Proteins / genetics*
Molecular Sequence Data
Molecular Weight
Plasmodium falciparum / genetics
Plasmodium falciparum / immunology*

Substances

Antigens, Protozoan
Membrane Proteins
DNA

Associated data

GENBANK/M27133
GENBANK/M27957