Abstract
The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Caenorhabditis / enzymology
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Caenorhabditis / genetics*
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Caenorhabditis / growth & development
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Cloning, Molecular
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DNA / genetics
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DNA / isolation & purification
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ErbB Receptors / genetics*
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Female
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Genes, ras
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Humans
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Molecular Sequence Data
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Nucleic Acid Hybridization
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Polymerase Chain Reaction
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Polymorphism, Restriction Fragment Length
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Protein-Tyrosine Kinases / genetics*
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RNA, Messenger / analysis
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Vulva / growth & development
Substances
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RNA, Messenger
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DNA
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ErbB Receptors
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Protein-Tyrosine Kinases