Abstract
The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor cell. It encodes a molecule similar to epidermal growth factor and to transforming growth factor-alpha and acts through the epidermal growth factor receptor homologue let-23. Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Animals, Genetically Modified
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Base Sequence
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Caenorhabditis / embryology*
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Caenorhabditis / genetics*
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Caenorhabditis elegans Proteins*
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Cloning, Molecular
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Disorders of Sex Development
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Embryonic Induction / genetics*
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Epidermal Growth Factor / genetics
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Female
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Helminth Proteins / genetics
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Molecular Sequence Data
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Recombinant Fusion Proteins
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Stem Cells / physiology
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Vulva / embryology
Substances
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Caenorhabditis elegans Proteins
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Helminth Proteins
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Recombinant Fusion Proteins
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Lin-3 protein, C elegans
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Epidermal Growth Factor